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Recovery of islet β-cell function in streptozotocin-induced diabetic mice : An indirect role for the spleen
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Recovery of islet β-cell function in streptozotocin-induced diabetic mice : An indirect role for the spleen
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Recovery of islet β-cell function in streptozotocin-induced diabetic mice : An indirect role for the spleen
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Journal Article
Recovery of islet β-cell function in streptozotocin-induced diabetic mice : An indirect role for the spleen
2006
Overview
Limitations in islet beta-cell transplantation as a therapeutic option for type 1 diabetes have prompted renewed interest in islet regeneration as a source of new islets. In this study we tested whether severely diabetic adult C57BL/6 mice can regenerate beta-cells. Diabetes was induced in C57BL/6 mice with high-dose streptozotocin (160-170 mg/kg). In the absence of islet transplantation, all diabetic mice remained diabetic (blood glucose >400 mg/dl), and no spontaneous reversal of diabetes was observed. When syngeneic islets (200/mouse) were transplanted into these diabetic mice under a single kidney capsule, stable restoration of euglycemia for >/=120 days was achieved. Removal of the kidney bearing the transplanted islets at 120 days posttransplantation revealed significant restoration of endogenous beta-cell function. This restoration of islet function was associated with increased beta-cell mass, as well as beta-cell hypertrophy and proliferation. The restoration of islet cell function was facilitated by the presence of a spleen; however, the facilitation was not due to the direct differentiation of spleen-derived cells into beta-cells. This study supports the possibility of restoring beta-cell function in diabetic individuals and points to a role for the spleen in facilitating this process.
Publisher
American Diabetes Association
Subject
/ Biological and medical sciences
/ Diabetes
/ Diabetes Mellitus, Experimental - blood
/ Diabetes Mellitus, Experimental - pathology
/ Diabetes Mellitus, Experimental - physiopathology
/ Diabetes. Impaired glucose tolerance
/ Endocrine pancreas. Apud cells (diseases)
/ Etiopathogenesis. Screening. Investigations. Target tissue resistance
/ Insulin-Secreting Cells - pathology
/ Insulin-Secreting Cells - physiology
/ Kinetics
/ Mice
/ Spleen
