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A \Silent\ Polymorphism in the MDR1 Gene Changes Substrate Specificity
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A \Silent\ Polymorphism in the MDR1 Gene Changes Substrate Specificity
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A \Silent\ Polymorphism in the MDR1 Gene Changes Substrate Specificity
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Journal Article
A \Silent\ Polymorphism in the MDR1 Gene Changes Substrate Specificity
2007
Overview
Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur. We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions. Similar mRNA and protein levels, but altered conformations, were found for wild-type and polymorphic P-gp. We hypothesize that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors
/ ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry
/ ATP-Binding Cassette, Sub-Family B, Member 1 - genetics
/ ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism
/ Biological and medical sciences
/ Cells
/ Codon
/ Codons
/ drugs
/ Fundamental and applied biological sciences. Psychology
/ genes
/ Genetics
/ Humans
/ Membrane and intracellular transports
/ Molecular and cellular biology
/ Polymorphism, Single Nucleotide
/ Proteins
/ Reverse Transcriptase Polymerase Chain Reaction
/ Rhodamine 123 - pharmacology
