Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

by Elinav, Eran , Gevers, Dirk , Narushima, Seiko , Kiguchi, Yuya , Hattori, Masahira , Rice, Scott A. , Thaiss, Christoph A. , Motoo, Iori , Toyooka, Kiminori , Johnson, Ryan C. , Chen, Kong , Yasuma, Keiko , Honda, Kenya , Segre, Julia A. , Luo, Chengwei , Atarashi, Koji , Kawaguchi, Takaaki , Watanabe, Eiichiro , Kolls, Jay K. , Sato, Mayuko , Tanoue, Takeshi , Morita, Hidetoshi , Xavier, Ramnik J. , Suda, Wataru , Yamagami, Hirokazu , Said, Heba S.

in Antibiotics / Bacteria / Cell proliferation / Colon / Colonization / Crohn's disease / Digestive system / Gastrointestinal tract / Germfree / Gnotobiotic / Inflammatory bowel disease / Inflammatory bowel diseases / Intestinal microflora / Intestine / Klebsiella / Land Settlement / Lymphocytes T / Mice / Microbiota / Oral cavity / Strains (organisms) / Ulcerative colitis

2017

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

2017

Confirm

Do you wish to request the book?

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

2017

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Elinav, Eran,

Gevers, Dirk,

Narushima, Seiko,

Kiguchi, Yuya,

Hattori, Masahira,

Rice, Scott A.,

Thaiss, Christoph A.,

Motoo, Iori,

Toyooka, Kiminori,

Johnson, Ryan C.,

Chen, Kong,

Yasuma, Keiko,

Honda, Kenya,

Segre, Julia A.,

Luo, Chengwei,

Atarashi, Koji,

Kawaguchi, Takaaki,

Watanabe, Eiichiro,

Kolls, Jay K.,

Sato, Mayuko,

Tanoue, Takeshi,

Morita, Hidetoshi,

Xavier, Ramnik J.,

Suda, Wataru,

Yamagami, Hirokazu,

Said, Heba S.

2017

Overview

Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.

Share this book

Add to My Shelf

Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

/ Colon