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A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D

by Osinusi, Anu , Aleman, Soo , Brunetto, Maurizia Rossana , Lampertico, Pietro , Blank, Antje , Geyvandova, Natalia , Stepanova, Tatyana , Morozov, Viacheslav , Da, Ben , Sagalova, Olga , Wedemeyer, Heiner , Mamonova, Nina , Schulze zur Wiesch, Julian , Andreone, Pietro , Suri, Vithika , Merle, Uta , Liu, Yang , Bogomolov, Pavel , Flaherty, John , Chulanov, Vladimir , Berger, Annemarie , An, Qi , Ciesek, Sandra , Manuilov, Dmitry , Cornberg, Markus , Zeuzem, Stefan

in Alanine transaminase / Antiviral Agents - administration & dosage / Antiviral Agents - adverse effects / Antiviral Agents - therapeutic use / Antiviral drugs / Arthralgia / Asthenia / Biopsy / Cirrhosis / Coinfection - drug therapy / Coinfection - virology / Disease / Eosinophilia / FDA approval / Gastroenterology / Gastroenterology General / Hepatitis B / Hepatitis B surface antigen / Hepatitis B Surface Antigens / Hepatitis B virus - genetics / Hepatitis B, Chronic - drug therapy / Hepatitis D, Chronic - drug therapy / Hepatitis delta virus / Hepatitis Delta Virus - genetics / Hepatocytes / Humans / Infections / Infectious Disease / Infectious Disease General / Interferon / Liver cirrhosis / Liver Disease / Liver diseases / Pruritus / Ribonucleic acid / RNA / Viral Infections

2023

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A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D

2023

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2023

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Journal Article

A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D

Osinusi, Anu,

Aleman, Soo,

Brunetto, Maurizia Rossana,

Lampertico, Pietro,

Blank, Antje,

Geyvandova, Natalia,

Stepanova, Tatyana,

Morozov, Viacheslav,

Da, Ben,

Sagalova, Olga,

Wedemeyer, Heiner,

Mamonova, Nina,

Schulze zur Wiesch, Julian,

Andreone, Pietro,

Suri, Vithika,

Merle, Uta,

Liu, Yang,

Bogomolov, Pavel,

Flaherty, John,

Chulanov, Vladimir,

Berger, Annemarie,

An, Qi,

Ciesek, Sandra,

Manuilov, Dmitry,

Cornberg, Markus,

Zeuzem, Stefan

2023

Overview

In a randomized trial, 48 weeks of treatment with bulevirtide, which inhibits hepatitis D virus entry into hepatocytes, reduced HDV RNA and alanine aminotransferase levels in patients with chronic hepatitis D.

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Publisher

Massachusetts Medical Society

Subject

Alanine transaminase

/ Antiviral Agents - administration & dosage

/ Antiviral Agents - adverse effects

/ Antiviral Agents - therapeutic use

/ Antiviral drugs

/ Arthralgia

/ Asthenia