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Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak
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Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak
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Journal Article
Rapid Whole-Genome Sequencing for Investigation of a Neonatal MRSA Outbreak
2012
Overview
Rapid whole-genome sequencing of microorganisms can identify relationships among clusters of infections. In this investigation of an outbreak of methicillin-resistant Staphylococcus aureus (MRSA), genomic sequencing helped to ascertain which cases were related.
Microbial whole-genome sequencing is poised to enhance diagnostic and public health microbiology.
1
–
3
Its discriminatory power has already been shown in a number of recent outbreaks, including cholera,
4
tuberculosis,
5
and
Escherichia coli
O104:H4.
6
,
7
The next step is to translate this technology from a research tool into one with clinical utility in the routine diagnostic setting. A compelling target is invasive methicillin-resistant
Staphylococcus aureus
(MRSA) infection, a major public health problem related primarily to health care.
8
In 2005, an estimated 94,360 invasive MRSA infections (including 18,900 hospital-acquired cases of bacteremia) occurred in the United States, associated with 18,650 deaths.
9
On . . .
Publisher
Massachusetts Medical Society
Subject
/ Babies
/ Cloning
/ Cross Infection - epidemiology
/ Cross Infection - microbiology
/ DNA
/ Genomes
/ Humans
/ Intensive Care Units, Neonatal
/ Methicillin Resistance - genetics
/ Methicillin-Resistant Staphylococcus aureus - genetics
/ Methicillin-Resistant Staphylococcus aureus - isolation & purification
/ Neonates
/ Polymorphism, Single Nucleotide
/ Sequence Analysis, DNA - methods
/ Single-nucleotide polymorphism
/ Staphylococcal Infections - epidemiology
