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Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration
by
Grunwald, Juan E
, Martin, Daniel F
, Jaffe, Glenn J
, Fine, Stuart L
, Maguire, Maureen G
, Ying, Gui-shuang
in
Age
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - pharmacology
/ Antibodies, Monoclonal - therapeutic use
/ Antibodies, Monoclonal, Humanized
/ Bevacizumab
/ Cardiovascular Diseases - epidemiology
/ Drug Administration Schedule
/ Female
/ Humans
/ Intention to Treat Analysis
/ Macular degeneration
/ Macular Degeneration - drug therapy
/ Macular Degeneration - pathology
/ Male
/ Medical imaging
/ Middle Aged
/ Off-Label Use
/ Older people
/ Proportional Hazards Models
/ Ranibizumab
/ Retina - drug effects
/ Retina - pathology
/ Single-Blind Method
/ Therapeutic Equivalency
/ Visual Acuity - drug effects
2011
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Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration
by
Grunwald, Juan E
, Martin, Daniel F
, Jaffe, Glenn J
, Fine, Stuart L
, Maguire, Maureen G
, Ying, Gui-shuang
in
Age
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - pharmacology
/ Antibodies, Monoclonal - therapeutic use
/ Antibodies, Monoclonal, Humanized
/ Bevacizumab
/ Cardiovascular Diseases - epidemiology
/ Drug Administration Schedule
/ Female
/ Humans
/ Intention to Treat Analysis
/ Macular degeneration
/ Macular Degeneration - drug therapy
/ Macular Degeneration - pathology
/ Male
/ Medical imaging
/ Middle Aged
/ Off-Label Use
/ Older people
/ Proportional Hazards Models
/ Ranibizumab
/ Retina - drug effects
/ Retina - pathology
/ Single-Blind Method
/ Therapeutic Equivalency
/ Visual Acuity - drug effects
2011
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Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration
by
Grunwald, Juan E
, Martin, Daniel F
, Jaffe, Glenn J
, Fine, Stuart L
, Maguire, Maureen G
, Ying, Gui-shuang
in
Age
/ Aged
/ Aged, 80 and over
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - pharmacology
/ Antibodies, Monoclonal - therapeutic use
/ Antibodies, Monoclonal, Humanized
/ Bevacizumab
/ Cardiovascular Diseases - epidemiology
/ Drug Administration Schedule
/ Female
/ Humans
/ Intention to Treat Analysis
/ Macular degeneration
/ Macular Degeneration - drug therapy
/ Macular Degeneration - pathology
/ Male
/ Medical imaging
/ Middle Aged
/ Off-Label Use
/ Older people
/ Proportional Hazards Models
/ Ranibizumab
/ Retina - drug effects
/ Retina - pathology
/ Single-Blind Method
/ Therapeutic Equivalency
/ Visual Acuity - drug effects
2011
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Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration
Journal Article
Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration
2011
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Overview
This comparison of ranibizumab and bevacizumab to treat neovascular age-related macular degeneration showed equivalent efficacy in maintaining visual acuity. Bevacizumab was associated with more serious adverse events (mainly hospitalizations).
In 2005, clinical trials established the efficacy of ranibizumab
1
,
2
(Lucentis, Genentech) for the treatment of neovascular age-related macular degeneration (AMD), the leading cause of legal blindness in the United States. While awaiting approval for ranibizumab from the Food and Drug Administration, ophthalmologists began treating neovascular AMD with off-label use of bevacizumab (Avastin, Genentech), since the drug had a target specificity similar to that of ranibizumab and was available at low cost.
3
,
4
Because the intraocular safety of bevacizumab and the duration of its therapeutic effect were unknown, the drug was usually administered only when there were signs of active . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Antibodies, Monoclonal - adverse effects
/ Antibodies, Monoclonal - pharmacology
/ Antibodies, Monoclonal - therapeutic use
/ Antibodies, Monoclonal, Humanized
/ Cardiovascular Diseases - epidemiology
/ Drug Administration Schedule
/ Female
/ Humans
/ Macular Degeneration - drug therapy
/ Macular Degeneration - pathology
/ Male
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