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Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

by Alings, Marco , Pombo, Marta , Benezet Mazuecos, Juan , Wright, David J. , Gold, Michael R. , Nevills, Sandra , McIntyre, William F. , Sticherling, Christian , Ip, John , Camm, A. John , Connolly, Stuart J. , Atar, Dan , Hohnloser, Stefan H. , Kaplan, Andrew , Linde, Cecilia , Boriani, Giuseppe , Simek, Kim , Rivard, Lena , Zarraga, Ignatius G. , Kautzner, Josef , Mian, Rajibul , Coutts, Shelagh B. , Mairesse, Georges , Conen, David , Mabo, Philippe , Wong, Jorge A. , Birnie, David H. , Healey, Jeff S. , Erath, Julia W. , Proietti, Marco , Granger, Christopher B. , Xu, Lizhen , Philippon, Francois , Ayala-Paredes, Felix , Lopes, Renato D. , Kutyifa, Valentina , Cosedis Nielsen, Jens

in Aged / Aged, 80 and over / Anticoagulants / Anticoagulants - adverse effects / Anticoagulants - therapeutic use / Anticoagulation / Arrhythmias / Aspirin / Aspirin - adverse effects / Aspirin - therapeutic use / Asymptomatic / Atrial Fibrillation - complications / Atrial Fibrillation - diagnosis / Bleeding / Canada / Cardiac arrhythmia / Cardiology / Clinical trials / Coagulation / Creatinine / Defibrillators / Double-Blind Method / Drug dosages / Embolism / Embolism - etiology / Embolism - prevention & control / Embolisms / Factor Xa Inhibitors - adverse effects / Factor Xa Inhibitors - therapeutic use / Female / Fibrillation / Hematology / Hemorrhage - chemically induced / Humans / Ischemia / Male / Medical research / Monitoring systems / Neurology / Neurosurgery / Oncology / Pacemakers / Patients / Pyridones - adverse effects / Statistical analysis / Stroke / Stroke - etiology / Stroke - prevention & control / Thromboembolism / Treatment Outcome

2024

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2024

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2024

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Journal Article

Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation

Alings, Marco,

Pombo, Marta,

Benezet Mazuecos, Juan,

Wright, David J.,

Gold, Michael R.,

Nevills, Sandra,

McIntyre, William F.,

Sticherling, Christian,

Ip, John,

Camm, A. John,

Connolly, Stuart J.,

Atar, Dan,

Hohnloser, Stefan H.,

Kaplan, Andrew,

Linde, Cecilia,

Boriani, Giuseppe,

Simek, Kim,

Rivard, Lena,

Zarraga, Ignatius G.,

Kautzner, Josef,

Mian, Rajibul,

Coutts, Shelagh B.,

Mairesse, Georges,

Conen, David,

Mabo, Philippe,

Wong, Jorge A.,

Birnie, David H.,

Healey, Jeff S.,

Erath, Julia W.,

Proietti, Marco,

Granger, Christopher B.,

Xu, Lizhen,

Philippon, Francois,

Ayala-Paredes, Felix,

Lopes, Renato D.,

Kutyifa, Valentina,

Cosedis Nielsen, Jens

2024

Overview

In a randomized trial involving patients with subclinical (typically asymptomatic) atrial fibrillation, apixaban led to a lower risk of stroke or systemic embolism than aspirin but a higher risk of major bleeding.

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Aged, 80 and over

/ Anticoagulants

/ Anticoagulants - adverse effects

/ Anticoagulants - therapeutic use

/ Anticoagulation

/ Arrhythmias