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Gene-Expression Profiling for Rejection Surveillance after Cardiac Transplantation
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Gene-Expression Profiling for Rejection Surveillance after Cardiac Transplantation
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Journal Article
Gene-Expression Profiling for Rejection Surveillance after Cardiac Transplantation
2010
Overview
Patients were assigned to monitoring for rejection after cardiac transplantation either according to the standard practice of endomyocardial biopsies or with gene-expression profiling. At 19 months, the rates of rejection with hemodynamic compromise, graft dysfunction, death, or retransplantation were similar in the two groups, although the power of the trial was limited.
Patients were assigned to monitoring for rejection after cardiac transplantation either according to the standard practice of endomyocardial biopsies or with gene-expression profiling. At 19 months, the rates of rejection were similar in the two groups.
Advances in immunosuppression after cardiac transplantation have increased the rates of 1-year survival among recipients to nearly 90%. However, acute cellular rejection is still observed during the first year after transplantation (at a rate of approximately 30 to 40%) and occurs at a lower rate thereafter.
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Rejection episodes are associated with an increased risk of allograft vasculopathy and loss.
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Endomyocardial biopsy has remained the primary method of monitoring for rejection, despite the discomfort and the rare but potentially serious complications of the procedure.
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Quantitative assessment of mononuclear-cell gene expression in peripheral-blood specimens has been explored as a . . .
Publisher
Massachusetts Medical Society
