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Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

by Grauer, Andreas , Karaplis, Andrew C , Thomas, Thierry , Lorentzon, Mattias , Meisner, Paul D , Saag, Kenneth G , Maddox, Judy , Brandi, Maria Luisa , Petersen, Jeffrey , Fan, Michelle

in Aged / Alendronate - adverse effects / Alendronate - pharmacology / Alendronate - therapeutic use / Alendronic acid / Antibodies, Monoclonal - adverse effects / Antibodies, Monoclonal - pharmacology / Antibodies, Monoclonal - therapeutic use / aorta / Bisphosphonates / Bone density / Bone Density - drug effects / Bone Density Conservation Agents - adverse effects / Bone Density Conservation Agents - pharmacology / Bone Density Conservation Agents - therapeutic use / Bone growth / Bone Remodeling - drug effects / Bone resorption / bone-mineral density / Cardiovascular Diseases - chemically induced / Clinical Medicine / disease / Double-Blind Method / Drug therapy / Drug Therapy, Combination / Female / Femur / Fractures / Fractures, Bone - epidemiology / Fractures, Bone - prevention & control / General & Internal Medicine / Hip / Humans / Immunoglobulins / Incidence / Inhibitor drugs / Jaw / Klinisk medicin / Least-Squares Analysis / metaanalysis / Monoclonal antibodies / Osteogenesis / Osteonecrosis / Osteoporosis / Osteoporosis, Postmenopausal - drug therapy / Post-menopause / postmenopausal women / randomized-trial / Risk / sclerosteosis / SOST protein / Spinal Fractures - epidemiology / Spinal Fractures - prevention & control / strength / Vertebrae / vertebral fractures / Womens health

2017

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Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

by Grauer, Andreas , Karaplis, Andrew C , Thomas, Thierry , Lorentzon, Mattias , Meisner, Paul D , Saag, Kenneth G , Maddox, Judy , Brandi, Maria Luisa , Petersen, Jeffrey , Fan, Michelle

2017

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Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

by Grauer, Andreas , Karaplis, Andrew C , Thomas, Thierry , Lorentzon, Mattias , Meisner, Paul D , Saag, Kenneth G , Maddox, Judy , Brandi, Maria Luisa , Petersen, Jeffrey , Fan, Michelle

2017

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Journal Article

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

Grauer, Andreas,

Karaplis, Andrew C,

Thomas, Thierry,

Lorentzon, Mattias,

Meisner, Paul D,

Saag, Kenneth G,

Maddox, Judy,

Brandi, Maria Luisa,

Petersen, Jeffrey,

Fan, Michelle

2017

Overview

Among postmenopausal women with osteoporosis and a high risk of fracture, treatment with the monoclonal antibody romosozumab for 12 months followed by alendronate resulted in a significantly lower risk of fracture than alendronate for 12 months followed by alendronate.

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Alendronate - adverse effects

/ Alendronate - pharmacology

/ Alendronate - therapeutic use

/ Alendronic acid

/ Antibodies, Monoclonal - adverse effects

/ Antibodies, Monoclonal - pharmacology