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A small-molecule screen identifies new functions for the plant hormone strigolactone
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Journal Article
A small-molecule screen identifies new functions for the plant hormone strigolactone
2010
Overview
Secretion of strigolactone from plant roots mediates mutualistic fungal interactions but also facilitates parasitic plant invasion. A screen in
Arabidopsis thaliana
has identified compounds that perturb strigolactone levels and link this hormone to light signaling pathways in host plants.
Parasitic weeds of the genera
Striga
and
Orobanche
are considered the most damaging agricultural agents in the developing world. An essential step in parasitic seed germination is sensing a group of structurally related compounds called strigolactones that are released by host plants. Although this makes strigolactone synthesis and action a major target of biotechnology, little fundamental information is known about this hormone. Chemical genetic screening using
Arabidopsis thaliana
as a platform identified a collection of related small molecules, cotylimides, which perturb strigolactone accumulation. Suppressor screens against select cotylimides identified light-signaling genes as positive regulators of strigolactone levels. Molecular analysis showed strigolactones regulate the nuclear localization of the COP1 ubiquitin ligase, which in part determines the levels of light regulators such as HY5. This information not only uncovers new functions for strigolactones but was also used to identify rice cultivars with reduced capacity to germinate parasitic seed.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Active Transport, Cell Nucleus - drug effects
/ Arabidopsis - growth & development
/ Arabidopsis Proteins - metabolism
/ Basic-Leucine Zipper Transcription Factors - metabolism
/ Chemistry and Materials Science
/ Genotype
/ Hormones
/ Hypocotyl - growth & development
/ Light
/ Nuclear Proteins - metabolism
/ Plant Growth Regulators - analysis
/ Plant Growth Regulators - chemistry
/ Plant Growth Regulators - metabolism
/ Plant Growth Regulators - pharmacology
/ Seedlings - growth & development
/ Seedlings - radiation effects
/ Small Molecule Libraries - chemistry
/ Ubiquitin-Conjugating Enzymes - metabolism
/ Weeds
