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Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae
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Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae
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Journal Article
Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae
2001
Overview
A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.
Publisher
Allen Press,International Leprosy Association
Subject
/ Animals
/ Bacterial Proteins - genetics
/ Bacterial Proteins - immunology
/ Bacterial Vaccines - administration & dosage
/ Biological and medical sciences
/ Leprosy
/ Leprosy - prevention & control
/ Mice
/ Mycobacterium leprae - growth & development
/ Mycobacterium leprae - pathogenicity
