Asset Details
Do you wish to reserve the book?
Inhaled corticosteroids in stable COPD patients: Do they have effects on cells and molecular mediators of airway inflammation?
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Inhaled corticosteroids in stable COPD patients: Do they have effects on cells and molecular mediators of airway inflammation?
Do you wish to request the book?
Inhaled corticosteroids in stable COPD patients: Do they have effects on cells and molecular mediators of airway inflammation?
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Inhaled corticosteroids in stable COPD patients: Do they have effects on cells and molecular mediators of airway inflammation?
2000
Overview
To investigate possible changes in cells and molecular mediators of airway inflammation following inhaled steroid treatment of stable COPD patients.
Six-week open preliminary prospective study.
A university respiratory disease clinic.
: Stable COPD patients with mild disease.
Six-week treatment with inhaled beclomethasone (1.5 mg die).
The levels of interleukin (IL)-8, myeloperoxidase, eosinophilic cationic protein and tryptase, and cell numbers in bronchial lavage specimens were determined, and the symptom score, the endoscopic bronchitis index, and functional parameters were recorded.
After treatment there were significant reductions in the lavage levels of IL-8 ([mean +/- SEM] 1,603.4 +/- 331.2 vs 1,119.2 +/- 265.3 pg/mL, respectively; p = 0. 01) and myeloperoxidase (1,614.5 +/- 682.3 vs 511.2 +/- 144.2 microg/L, respectively; p = 0.05), in cell numbers (250.6 +/- 27.7 vs 186.3 +/- 11.5 cells x 10(3)/mL, respectively; p = 0.04), neutrophil proportion (59.7 +/- 14.3% vs 31.5 +/- 10.1%; p = 0.01), symptom score (4.5 +/- 0.6 vs 1.4 +/- 0.5; p = 0.01), and bronchitis index (8.5 +/- 0.8 vs 5.5 +/- 0.7; p = 0.007).
In stable patients with COPD, inhaled steroid treatment may induce changes on some cellular and molecular parameters of airway inflammation.
Publisher
American College of Chest Physicians
Subject
/ Aged
/ Anti-Inflammatory Agents - administration & dosage
/ Anti-Inflammatory Agents - adverse effects
/ Asthma
/ Beclomethasone - administration & dosage
/ Beclomethasone - adverse effects
/ Biological and medical sciences
/ Bronchoalveolar Lavage Fluid - immunology
/ Chronic obstructive pulmonary disease
/ Female
/ Forced Expiratory Volume - drug effects
/ Humans
/ Inflammation Mediators - metabolism
/ Lavage
/ Leukocyte Count - drug effects
/ Lung Diseases, Obstructive - drug therapy
/ Lung Diseases, Obstructive - immunology
/ Male
/ Patients
/ Pharmacology. Drug treatments
/ Smoking
/ Steroids
