Asset Details
Do you wish to reserve the book?
A cynomolgus macaque model for Crimean–Congo haemorrhagic fever
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A cynomolgus macaque model for Crimean–Congo haemorrhagic fever
Do you wish to request the book?
A cynomolgus macaque model for Crimean–Congo haemorrhagic fever
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A cynomolgus macaque model for Crimean–Congo haemorrhagic fever
2018
Overview
Crimean–Congo haemorrhagic fever (CCHF) is the most medically significant tick-borne disease, being widespread in the Middle East, Asia, Africa and parts of Europe
1
. Increasing case numbers, westerly movement and broadly ranging case fatality rates substantiate the concern of CCHF as a public health threat. Ixodid ticks of the genus
Hyalomma
are the vector for CCHF virus (CCHFV), an arbovirus in the genus
Orthonairovirus
of the family Nairoviridae. CCHFV naturally infects numerous wild and domestic animals via tick bite without causing obvious disease
2
,
3
. Severe disease occurs only in humans and transmission usually happens through tick bite or contact with infected animals or humans. The only CCHF disease model is a subset of immunocompromised mice
4
–
6
. Here, we show that following CCHFV infection, cynomolgus macaques exhibited hallmark signs of human CCHF with remarkably similar viral dissemination, organ pathology and disease progression. Histopathology showed infection of hepatocytes, endothelial cells and monocytes and fatal outcome seemed associated with endothelial dysfunction manifesting in a clinical shock syndrome with coagulopathy. This non-human primate model will be an invaluable asset for CCHFV countermeasures development.
This study describes the development of a primate model for Crimean–Congo haemorrhagic fever, the first immunocompetent animal model, which will be instrumental in developing and testing medical countermeasures for this serious disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 59
/ 692/420
/ Animals
/ Biomedical and Life Sciences
/ Endothelial Cells - virology
/ Female
/ Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity
/ Hemorrhagic Fever, Crimean - complications
/ Hemorrhagic Fever, Crimean - mortality
/ Hemorrhagic Fever, Crimean - pathology
/ Hemorrhagic Fever, Crimean - virology
/ Humans
/ Letter
/ Macaca
/ Male
/ Virology
