Asset Details
Do you wish to reserve the book?
Liver resection for hepatocellular and fibrolamellar carcinoma in a South African tertiary referral centre – an observational cohort analysis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Liver resection for hepatocellular and fibrolamellar carcinoma in a South African tertiary referral centre – an observational cohort analysis
Do you wish to request the book?
Liver resection for hepatocellular and fibrolamellar carcinoma in a South African tertiary referral centre – an observational cohort analysis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Liver resection for hepatocellular and fibrolamellar carcinoma in a South African tertiary referral centre – an observational cohort analysis
2024
Overview
BackgroundMore than 80% of global hepatocellular carcinomas (HCC) occur in sub-Saharan Africa (SSA) and South-East Asia. Compared with the rest of the world, HCC in SSA has the lowest resection and survival rates. This study assessed outcome following liver resection for HCC and fibrolamellar carcinoma (FLC) at a tertiary referral centre in South Africa.MethodsA retrospective analysis was done of all liver resections for HCC and FLC at Groote Schuur Hospital and the University of Cape Town Private Academic Hospital between January 1990 and December 2021. Three groups were compared, (i) HCC occurring in normal livers, (ii) HCC occurring in cirrhotic livers, and (iii) fibrolamellar carcinoma. Postoperative complications were classified as per the expanded accordion severity grading system. Median overall survival (OS) and 95% confidence intervals (CI) were calculated.ResultsForty-eight patients were included in the study, 25 for HCC in non-cirrhotic livers, 15 in cirrhotic livers and eight for FLC. Thirty-six patients (75%) underwent a major resection. No mortality occurred but 16 patients (33%) developed grade 1 to 4 complications postoperatively. Thirty-three patients (69%) developed recurrence of HCC following their initial resection of whom 29 (60%) ultimately died. Median overall survival (OS) for the total cohort after surgery was 57.2 months, 95% CI (29.7–84.6), 64.2 months (29.7–84.6), 61.9 months (28.1–95.6), and 31.7 months (1.5–61.8) for patients with HCC in non-cirrhotic livers, FLC and HCC in cirrhotic livers respectively.ConclusionsLiver resection for HCC and FLC was safe with no mortality, but one-third of patients had associated postoperative morbidity. The high long-term recurrence rate remains a major obstacle in achieving better survival results after resection.
Publisher
Medpharm Publications
Subject
