Asset Details
Do you wish to reserve the book?
A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms
Do you wish to request the book?
A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms
2022
Overview
Sporotrichosis is a subcutaneous mycosis that affects humans and animals, with few therapeutic options available in the pharmaceutical market. We screened the in vitro antifungal activity of fourteen 1,4-naphthoquinones derivative compounds against
Sporothrix brasiliensis
and
Sporothrix schenckii
, the main etiological agents of sporotrichosis in Latin America. The most active compound was selected for further studies exploring its antibiofilm activity, effects on yeast morphophysiology, interaction with itraconazole, and selectivity to fungal cells. Among the fourteen 1,4-naphthoquinones tested, naphthoquinone
5
, a silver salt of lawsone, was the most active compound. Naphthoquinone
5
was able to inhibit
Sporothrix
biofilms and induced ROS accumulation, mitochondrial disturbances, and severe plasmatic membrane damage in fungal cells. Furthermore, naphthoquinone
5
was ten times more selective towards fungal cells than fibroblast, and the combination of itraconazole with naphthoquinone
5
improved the inhibitory activity of the azole. Combined, the data presented here indicate that the silver salt naphthoquinone
5
exerts promising in vitro activity against the two main agents of sporotrichosis with important antibiofilm activity and a good toxicity profile, suggesting it is a promising molecule for the development of a new family of antifungals.
Publisher
Springer International Publishing,Springer Nature B.V
Subject
/ Antifungal Agents - pharmacology
/ Antifungal Agents - therapeutic use
/ Biofilms
/ Biomedical and Life Sciences
/ Clinical Microbiology - Research Paper
/ Etiology
/ Fungi
/ Glucose
/ Itraconazole - therapeutic use
/ Microbial Genetics and Genomics
/ Mycology
/ Mycosis
/ Naphthoquinones - pharmacology
/ Sporotrichosis - microbiology
/ Toxicity
/ Yeast
/ Zoonoses
