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Deciphering the Role of ADAMTS6 in the Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells
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Journal Article
Deciphering the Role of ADAMTS6 in the Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells
2025
Overview
A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) is an extracellular matrix (ECM) protease that promotes the invasion of lung adenocarcinoma (LUAD) cells. Herein, we investigate its role in epithelial-mesenchymal transition (EMT), a process that drives metastasis and drug resistance in LUAD. Re-analysis of microarray and RNA sequencing data from LUAD cells revealed that during EMT, TGF-β1 increased
expression, presumably through the SMAD pathway, as SMAD2 loss completely blocked this effect. Moreover,
was shown to occupy hub positions within TGF-β1-associated gene networks. Using additional datasets, we found that
expression increased under other EMT-inducing conditions, including IL-1β induction and acquired gefitinib resistance, but decreased upon knockdown of Twist1, a master regulator of EMT. Knockout of
repressed colony formation, migration, invasion, and doxorubicin resistance but enhanced cell-ECM adhesion in A549 cells. This effect was mediated by EMT inhibition, evidenced by upregulation of E-cadherin and downregulation of N-cadherin, vimentin, and Twist1, and was accompanied by suppressed nuclear translocation of the NF-κB p65 subunit. Re-analysis of transcriptomic data from patient tumors demonstrated that high
expression correlated with the expression of EMT markers, further supporting the
-EMT link. Moreover, high
expression was associated with worse survival prognosis. Overall,
promotes EMT in LUAD cells and may be considered a marker of this process, as well as a potential therapeutic target for its inhibition.
Publisher
MDPI AG,Multidisciplinary Digital Publishing Institute (MDPI)
Subject
/ ADAMTS Proteins - metabolism
/ Adenocarcinoma of Lung - genetics
/ Adenocarcinoma of Lung - metabolism
/ Adenocarcinoma of Lung - pathology
/ Datasets
/ Drug Resistance, Neoplasm - genetics
/ Epithelial-Mesenchymal Transition - genetics
/ Gene Expression Regulation, Neoplastic
/ Genes
/ Humans
/ Nuclear Proteins - metabolism
/ Transforming Growth Factor beta1 - genetics
/ Transforming Growth Factor beta1 - metabolism
