Journal Article

CSF-tau and CSF-Abeta(1-42) in posterior cortical atrophy

Sollberger, Marc, Gomez-Mancilla, Baltazar, Kuhle, Jens, Regeniter, Axel, Baumann, Thomas P, Schmidtke, Klaus, Monsch, Andreas U, Duyar, Hüseyin

2010

Overview

Our purpose was to measure Abeta(1-42), T-tau and P-tau(181) in the cerebrospinal fluid (CSF) of patients with posterior cortical atrophy (PCA), a presenile dementia likely to represent a variant of Alzheimer's disease (AD). CSF samples from 34 subjects including 9 patients with PCA, 11 age-matched patients with AD and 14 age-matched cognitively healthy controls were analyzed using commercially available ELISA kits. The Abeta(1-42), T-tau and P-tau(181) levels in PCA patients differed significantly (p < 0.02) from those in healthy controls but were indistinguishable from subjects with a clinical diagnosis of AD. High T-tau and P-tau(181) and low Abeta(1-42) levels in PCA - typically observed in AD - indicate that the underlying pathology of PCA is usually AD. If these findings are replicated in PCA patients with autopsy-confirmed AD neuropathology, PCA patients may be eligible for disease-modifying AD treatments.

• Subject: Aged / Alzheimer Disease - cerebrospinal fluid / Alzheimer Disease - classification / Alzheimer Disease - pathology / Amyloid beta-Peptides - cerebrospinal fluid / Atrophy - cerebrospinal fluid / Biomarkers - cerebrospinal fluid / Brain - pathology / Case-Control Studies / Cognition Disorders - cerebrospinal fluid / Cognition Disorders - pathology / Dementia - cerebrospinal fluid / Dementia - classification / Dementia - pathology / Female / Humans / Male / Matched-Pair Analysis / Middle Aged / Peptide Fragments - cerebrospinal fluid / Reference Values / tau Proteins - cerebrospinal fluid