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Biological Studies on some Nutritional Products Supplemented with Fish Oil for Hyperlepidmic Rats
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Journal Article
Biological Studies on some Nutritional Products Supplemented with Fish Oil for Hyperlepidmic Rats
2015
Overview
Reducing intake of saturated fat, dietary cholesterol and avoiding excess calories, which can lead to obesity, remain the cornerstone of the dietary approach to decreasing risk of atherosclerotic vascular disease. During the past 20 years, there has been renewed interest in other dietary components that might favorably improve lipid profiles and reduce risk of coronary heart disease (CHD). Fish oil, rich sources of omega-3 fatty acids, have sparked intense interest in both epidemiological studies, which suggest a favorable effect on CHD, and metabolic ward studies, which show a striking improvement in lipid profiles in hyperlipidemic patients. This research aimed to study the biological properties of some nutritional products supplemented with fish oil on hyperlipidemic rats. Thirty female albino rats (30 female), weighing 140 ±5g were divided into 6 groups and administered fish oil products daily for 28 days. Blood samples were taken from each rat and tested for total cholesterol, (LDL), (HDL), triglycerides, liver enzymes activities, kidney functions, progesterone and PRL hormone. Results showed that triglycerides, total cholesterol, LDL, VLDL, and liver enzymes activities (AST and ALT) were significantly increased, while HDL was significantly decreased in positive control group compared with the negative control rats. Treating hypercholesterolemic rats with 20% pizza contained 10% and 15% fish oil in hypercholesterolemic diet caused a significant improvement in these biochemical measures and the best results were achieved by using basal diet with 20% pizza contained (15%) fish oil. So, it could be concluded that fish oil is useful for hyperlipidemic patients and for the prevention of heart disease and hardening of the arteries.
Publisher
جامعة طنطا - كلية التربية النوعية
Subject
