Journal Article

Preventive Effect of Prunes \Prunus Domestica\ & Raisins \Vitis Vinifera\ Muffins Stuffed and their Mixture on Rats with Irritable Bowel Syndrome

Abd Elnaser, Eman, Elzamzamy, Fatma M, Ramadan, Afaf Haniem M, El-Ezaly, Fayza M

2024

Overview

This study focused on identifying the preventive effect of prunes (Prunus domestica) & raisins (Vitis vinifera) mixture and muffin stuffed with them on rats injured with irritable bowel syndrome. Rats male albino weighing 170 ± 15 g (n=30), were randomly assigned to five groups of 6 rats per each. The 1st group fed basal diet was served as a normal control (-ve), and the remaining four groups were classified into (+ve) control group (fed on basal diet only), groups of 3, 4, and 5 were fed basal diet containing 20% of (normal muffins (N), or best muffin formula or dried fruit mixture). Irritable bowel syndrome was induced from the beginning of experiment by using 50 μl mustard oil (1% in 70% ethanol) by intra colonic administration. The results indicated that the best muffin formula recorded the highest total phenols content (427.60 mg/100g), and total antioxidant activity (45.44%) comparing to normal muffin. Irritable bowel syndrome rats group fed the best muffin formula showed significant increase in some nutritional parameters as weight gain, food intake and feed efficiency ratio comparing with (+ve) positive control group, decreased levels of free radicals (malondialdehyde (MDA) and hydrogen peroxide (H2O2), while increasing in antioxidant enzymes such as, glutathione peroxidase (GSH) , superoxide dismutase (SOD) and catalase activity (CAT). Furthermore, the same group recorded significant decreases in anti-inflammatory factors namely, (C-reactive protein (CRP), Interleukin-6 (IL-6) and Cyclooxygenase 2 protein (COX2), and significant increase serum serotonin hormone comparison with positive group at p <0.05. On the other hand, a significant decrease in anti-inflammatory indicators and a significant increase in the hormone serotonin were observed in all groups Protictive with muffins stuffed with dried fruits or dried fruit mixture. In conclusion, muffin stuffed with dried fruits such as raisins and prunes which are baked dough products are considered a functional and protective food that is promising in protecting the gastrointestinal system from inflammation, especially irritable bowel syndrome.

• Publisher: جامعة المنصورة - كلية التربية النوعية
• Subject: الأنظمة الغذائية / التأثيرات الوقائية / خلطة المافن / فئران التجارب / متلازمة القولون العصبي