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Sodium chloride drives autoimmune disease by the induction of pathogenic T^sub H^17 cells
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Sodium chloride drives autoimmune disease by the induction of pathogenic T^sub H^17 cells
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Journal Article
Sodium chloride drives autoimmune disease by the induction of pathogenic T^sub H^17 cells
2013
Overview
Macrophages residing in the skin interstitium modulate local electrolyte composition in response to NaCl-mediated extracellular hypertonicity, and their regulatory activity provides a bufferingmechanismfor salt-sensitive hypertension7.Moreover, blockade of the renin-angiotensin system, can modulate immune responses and affect EAE8,9. [...]to investigate whether increased NaCl intake might have a direct effect on CD41 T-cell populations and therefore represents a risk factor for autoimmune diseases, we investigated the effect of NaCl on the in vitro differentiation of human TH17 cells. The CD41 cells expressed high levels of the NFAT5 targets SGK1 (ref. 22) and the sodium/myo-inositol cotransporter SLC5A3 (Fig. 2a, b and Supplementary Figs 7 and 8)21,23. [...]we proposed that increased NaCl concentration leads to phosphorylation of p38/MAPK that activates other downstream targets, including NFAT5.
Publisher
Nature Publishing Group
Subject
