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Single chain MHC I trimer-based DNA vaccines for protection againstListeria monocytogenesinfection
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Single chain MHC I trimer-based DNA vaccines for protection againstListeria monocytogenesinfection
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Journal Article
Single chain MHC I trimer-based DNA vaccines for protection againstListeria monocytogenesinfection
2012
Overview
Highlights * We tested a MHC I/peptide single chain DNA vaccine againstListeriainfection in mice. * This approach was designed to optimize antigen presentation to CD8+T cells. * Kd/LLO single chain DNA vaccine elicited CD8+T cells and reduced bacterial loads. * Helper T cell responses improved memory but not primary anti-bacterial responses. * Single chain approaches should be considered as part of a composite vaccine.
Publisher
Elsevier Limited
Subject
