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Ranolazine inhibits NaV 1.5-mediated breast cancer cell invasiveness and lung colonization
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Ranolazine inhibits NaV 1.5-mediated breast cancer cell invasiveness and lung colonization
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Journal Article
Ranolazine inhibits NaV 1.5-mediated breast cancer cell invasiveness and lung colonization
2014
Overview
Doc number: 264 Abstract Background: NaV 1.5 voltage-gated sodium channels are abnormally expressed in breast tumours and their expression level is associated with metastatic occurrence and patients' death. In breast cancer cells, NaV 1.5 activity promotes the proteolytic degradation of the extracellular matrix and enhances cell invasiveness. Findings: In this study, we showed that the extinction of NaV 1.5 expression in human breast cancer cells almost completely abrogated lung colonisation in immunodepressed mice (NMRI nude). Furthermore, we demonstrated that ranolazine (50 μM) inhibited NaV 1.5 currents in breast cancer cells and reduced NaV 1.5-related cancer cell invasiveness in vitro. In vivo , the injection of ranolazine (50 mg/kg/day) significantly reduced lung colonisation by NaV 1.5-expressing human breast cancer cells. Conclusions: Taken together, our results demonstrate the importance of NaV 1.5 in the metastatic colonisation of organs by breast cancer cells and indicate that small molecules interfering with NaV activity, such as ranolazine, may represent powerful pharmacological tools to inhibit metastatic development and improve cancer treatments.
Publisher
Springer Nature B.V
Subject
