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Alcohol's Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury

by Katz, Paige S , Teng, Sophie X , Mayeux, Jacques P , Maxi, John K , d, Stephen M , Molina, Patricia E , Souza-Smith, Flavia , Dodd, Tracy Y

in Alcohol / Alcohol related accidents / Alcohol use / Alcoholism / Bacteria / Brain damage / Burns / Cytokines / Drinking behavior / Immune response / Immune system / Immunity / Injuries / Morbidity / Mortality / Mortality rates / Patients / Susceptibility / Trauma / Traumatic brain injury

2015

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Alcohol's Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury

by Katz, Paige S , Teng, Sophie X , Mayeux, Jacques P , Maxi, John K , d, Stephen M , Molina, Patricia E , Souza-Smith, Flavia , Dodd, Tracy Y

2015

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Alcohol's Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury

by Katz, Paige S , Teng, Sophie X , Mayeux, Jacques P , Maxi, John K , d, Stephen M , Molina, Patricia E , Souza-Smith, Flavia , Dodd, Tracy Y

2015

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Journal Article

Alcohol's Burden on Immunity Following Burn, Hemorrhagic Shock, or Traumatic Brain Injury

Katz, Paige S,

Teng, Sophie X,

Mayeux, Jacques P,

Maxi, John K,

d, Stephen M,

Molina, Patricia E,

Souza-Smith, Flavia,

Dodd, Tracy Y

2015

Overview

Alcohol consumption contributes to increased incidence and severity of traumatic injury. Compared with patients who do not consume alcohol, alcohol-consuming patients have higher rates of long-term morbidity and mortality during recovery from injury. This can be attributed in part to an impaired immune response in individuals who consume alcohol. Acute and chronic alcohol use can affect both the innate and adaptive immune defense responses within multiple organ systems; the combination of alcohol use and injury results in increased susceptibility to bacterial and viral pathogens. This review examines the major deleterious effects of alcohol on immunity following tissue damage or traumatic injury, with a focus on alcohol's influence on the ability of the immune and major organ systems to fight disease and to repair damaged tissues following injury.

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Publisher

Superintendent of Documents

Subject

Alcohol

/ Alcohol related accidents

/ Burns