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Oral cancer and precancer in bone marrow transplantated patients affected by chronic graft versus host disease
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Oral cancer and precancer in bone marrow transplantated patients affected by chronic graft versus host disease
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Journal Article
Oral cancer and precancer in bone marrow transplantated patients affected by chronic graft versus host disease
2015
Overview
This work was aimed at describing the development of oral cancer and precancer in patients affected by cGVHD, thus suggesting the importance of periodical follow-up to detect premalignant or malignant lesions at an early stage. Forty patients who underwent aBMT from consanguineous and with a diagnosis of cGVHD came to our attention to the Complex Operating Unit of Odontostomatology, Policlinic of Bari; 19 of them showed 47 lesions on different oral sites which clinically appeared as: 1. leuko-erythroplastic lesions (79%), 2. ulcers (12%), and nodules (9%). All these lesions underwent incisional biopsy and histopathological analysis; specifically for neoplastic tissues, 6 prognostic factors were also evaluated: tumor thickness, invasion pattern (single cell, large front), vascular, neural, salivary glands ducts and muscle infiltration. All the surgical wounds healed without complications. The histopathological examination of the surgical samples highlighted that: 52% were oral cancers, 31% were precancerous lesions (OIN 1 and 2) and 17% were hyperkeratotic or lichenoid lesions.
Publisher
CIC Edizioni Internazionali
Subject
