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Technique discussion of CRISPR babies -A comment to Jiankui He's research
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Technique discussion of CRISPR babies -A comment to Jiankui He's research
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Journal Article
Technique discussion of CRISPR babies -A comment to Jiankui He's research
2018
Overview
[...]it has been scolded for years that some talented scientists behave abusively in the lab. [...]Dr. He has considered the off-target effects of CRISPR/Cas9 system, but the single-cell sequencing technology used to exclude off-target effects, which can only cover 80% of the whole genome, was not sufficient to ensure safety 5. [...]the truncated C-C chemokine receptor 5 (CCR5) in Nana (-4, +1) is completely different from the CCR5A32 discovered in European, leaving potential risks of creating a toxic protein and unwanted effects that are impossible to foresee. [...]besides the fact that Lulu's genes cannot possibly give her protection against HIV, researchers have already developed multiple strategies to protect newborn from vertical transmission 6. [...]in Dr. He's research, it is the twins' father infected with HIV.
Publisher
E-Discovery Publication Inc
Subject
