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Effects of lncRNA DOCK9-AS2 on the proliferation and migration of papillary thyroid carcinoma cells / 长链非编码RNA DOCK9-AS2对甲状腺乳头状癌细胞增殖和迁移的影响
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Effects of lncRNA DOCK9-AS2 on the proliferation and migration of papillary thyroid carcinoma cells / 长链非编码RNA DOCK9-AS2对甲状腺乳头状癌细胞增殖和迁移的影响
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Effects of lncRNA DOCK9-AS2 on the proliferation and migration of papillary thyroid carcinoma cells / 长链非编码RNA DOCK9-AS2对甲状腺乳头状癌细胞增殖和迁移的影响
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Journal Article
Effects of lncRNA DOCK9-AS2 on the proliferation and migration of papillary thyroid carcinoma cells / 长链非编码RNA DOCK9-AS2对甲状腺乳头状癌细胞增殖和迁移的影响
2018
Overview
Objective: To detect the expression of long non-coding RNAs (lncRNAs) DOCK9-AS2 in papillary thyroid carcinoma (PTC) and its effects on the proliferation and migration of PTC cells. Methods: PTC samples and the corresponding adjacent tissues were collected from The First Affiliated Hospital of Nanjing Medical University during June 2016 and June 2017. The qRT-PCR was performed to detected the expression of DOCK9-AS2 in the tissues, and the relationship between DOCK9-AS2 expression and the patients clinicopathological data was analyzed. The cell transfection technology was used to establish the PTC BCPAP cell downregulating DOCK9-AS2 stably. CCK8 was carried out to investigate the effect of DOCK9-AS2 on the proliferation of the BCPAP cells. The wound-healing assay was used to dectect the effect of DOCK9-AS2 on the migration of the BCPAP cells. Results: : The expression of DOCK9-AS2 in PTC tissues (0.0097±0.0044) was significantly higher than that of adjacent tissues (0.0026±0.0010) (P<0.05). The expression of
Publisher
Xi'an Jiaotong University
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