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Prediction of transition from common adolescent bipolarexperiences to bipolar disorder: 10-year study
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Prediction of transition from common adolescent bipolarexperiences to bipolar disorder: 10-year study
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Journal Article
Prediction of transition from common adolescent bipolarexperiences to bipolar disorder: 10-year study
2010
Overview
BackgroundAlthough (hypo)manic symptoms are common in adolescence, transition toadult bipolar disorder is infrequent.AimsTo examine whether the risk of transition to bipolar disorder isconditional on the extent of persistence of subthreshold affectivephenotypes.MethodIn a 10-year prospective community cohort study of 3021 adolescents andyoung adults, the association between persistence of affective symptomsover 3 years and the 10-year clinical outcomes of incident DSM–IV(hypo)manic episodes and incident use of mental healthcare wasassessed.ResultsTransition to clinical outcome was associated with persistence ofsymptoms in a dose-dependent manner. Around 30–40% of clinical outcomescould be traced to prior persistence of affective symptoms.ConclusionsIn a substantial proportion of individuals, onset of clinical bipolardisorder may be seen as the poor outcome of a developmentally common andusually transitory non-clinical bipolar phenotype.
