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m6A RNA modification as a new player in R-loop regulation
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m6A RNA modification as a new player in R-loop regulation
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Journal Article
m6A RNA modification as a new player in R-loop regulation
2020
Overview
The list of physiological processes affected by m6A is expanding and includes DNA-damage6 and viral-infection responses, cell differentiation, brain development, cell growth and tumor progression5,7,8. m6A regulates R-loop stability In their study, Abakir et al. adapted the antibody-based DNA: Genome-stability consequences and beyond One of the most remarkable findings of this study is that depletion of YTHDF2 and METTL3 (the writer that deposits m6A) increases levels of yH2AX, a marker of DNA double-strand breaks, thus suggesting that pathological R-loop accumulation in the absence of the m6A RNA-methylation pathway challenges genome integrity. [...]dysregulation of R-loops is emerging as a critical factor driving genome instability in a large variety of pathological contexts, including after oncogenic stress12, in cells infected with Kaposi's sarcoma-associated herpesvirus, in neurological disorders associated with trinucleotide-repeat expansion (such as Huntington's disease and fragile X syndrome) and in multiple other inherited ataxias (for example, ataxia with oculomotor apraxia 2)2.
