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Per- and Polyfluoroalkyl Substances and Anti-Miillerian Hormone Concentrations in Two Preconception Cohort Studies
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Per- and Polyfluoroalkyl Substances and Anti-Miillerian Hormone Concentrations in Two Preconception Cohort Studies
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Journal Article
Per- and Polyfluoroalkyl Substances and Anti-Miillerian Hormone Concentrations in Two Preconception Cohort Studies
2023
Overview
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent synthetic chemicals found in consumer products, fire-fighting foam, and contaminated food and water. Routes of exposure include ingestion, inhalation, and dermal absorption. Several PFAS have long biological half-lives and can bioaccumulate in living organisms. Although the prevalence of commonly manufactured PFAS in the US has decreased since 2000 following phase-outs and chemical substitutions, their detection in humans remains high. Anti-Mullerian hormone (AMH), an established biomarker of ovarian reserve, can be accurately measured from a single blood sample at any time during the menstrual cycle because AMH shows little within-cycle variation. AMH concentrations generally decline across the reproductive life span and are considered useful in predicting the liming of menopause. Two prospective cohort studies of PFAS and AMH concentrations among adults reported null associations, however, sample sizes were small (range: 55-99). To build on prior literature, we evaluated the association between PFAS and AMH among 357 noncontracepting individuals residing in diverse geographic areas with wider exposure variability and greater sample size.
Publisher
National Institute of Environmental Health Sciences
Subject
