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An Overview of Genetic Biomarkers Influencing Drug Response and Efficacy in Specific Populations

by Rasheed Saeed Ali Alghamdi , Mohammed Obaidallah Obaid Almatrafi , Nourah Gherman Salman Al-Amri , Nabial Hamadi Al Sheikh , Ahmad Khalid Damanhouri , Abdullah Hassan Alhumrani , Waad Hamed Alsharif , Abdulaziz Faihan Mashan Alotaibi , Sharif Wusayman Lafi Alharbi , Ismaeel Mohamed Sardar , Aljohara Mohammed Hasan Halikah , Najat Khalaf Almashyakhi , Ahmed Habib Aelnakhly , Mahmoud Khamis Saeed Alghamdi , Khaled Mohammed Hamed Alamri

in Antidepressants / Antigens / Asian people / Biomarkers / Clinical medicine / Collaboration / Cytochrome / Drug dosages / Enzymes / Genetic testing / Hospitals / Laboratories / Leukocytes / Metabolism / Precision medicine / Side effects / Toxicity

2024

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An Overview of Genetic Biomarkers Influencing Drug Response and Efficacy in Specific Populations

2024

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An Overview of Genetic Biomarkers Influencing Drug Response and Efficacy in Specific Populations

2024

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Journal Article

An Overview of Genetic Biomarkers Influencing Drug Response and Efficacy in Specific Populations

Rasheed Saeed Ali Alghamdi,

Mohammed Obaidallah Obaid Almatrafi,

Nourah Gherman Salman Al-Amri,

Nabial Hamadi Al Sheikh,

Ahmad Khalid Damanhouri,

Abdullah Hassan Alhumrani,

Waad Hamed Alsharif,

Abdulaziz Faihan Mashan Alotaibi,

Sharif Wusayman Lafi Alharbi,

Ismaeel Mohamed Sardar,

Aljohara Mohammed Hasan Halikah,

Najat Khalaf Almashyakhi,

Ahmed Habib Aelnakhly,

Mahmoud Khamis Saeed Alghamdi,

Khaled Mohammed Hamed Alamri

2024

Overview

This review examines the role of genetic biomarkers in influencing drug response and efficacy, focusing on their impact in specific populations and the challenges in implementing pharmacogenomics in clinical practice. Genetic biomarkers, such as polymorphisms in CYP450 enzymes, HLA alleles, and TPMT, significantly affect drug metabolism, efficacy, and the risk of adverse reactions. Population-specific genetic differences, such as HLA-B15:02 in Southeast Asians and CYP2C19 variants in East Asians, highlight the importance of tailoring pharmacogenomic insights to diverse groups. While pharmacogenomics holds immense promise for personalized medicine, barriers such as limited population diversity in genomic research, high testing costs, and integration challenges hinder its widespread application. Addressing these issues through collaborative efforts and advancing equitable access to genetic testing can unlock the potential of pharmacogenomics to optimize therapeutic outcomes and reduce disparities in healthcare.

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Nicholson School of Communication and Media at the University of Central Florida

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