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Clonal evolution in relapsed acutemyeloid leukaemia revealed by whole-genome sequencing

by Tomasson, Michael H , Shannon, William D , Wilson, Richard K , Lu, Charles , Kalicki-Veizer, Joelle , McLellan, Michael D , Mardis, Elaine R , Lamprecht, Tamara , Westervelt, Peter , DiPersio, John F , Link, Daniel C , Fulton, Robert S , Payton, Jacqueline E , Ding, Li , Ritchey, Julie K , Larson, David E , Heath, Sharon , Fulton, Lucinda L , Watson, Mark A , McGrath, Sean D , Kulkarni, Shashikant , Wendl, Michael C , Welch, John S , Magrini, Vincent J , Shen, Dong , Graubert, Timothy A , Walter, Matthew J , Wallis, John W , Ley, Timothy J , Young, Margaret A , McMichael, Joshua F , Dooling, David J , Cook, Lisa , Vickery, Tammi L , Chen, Ken , Miller, Christopher A , Harris, Christopher C , Koboldt, Daniel C , Schmidt, Heather

in Bone marrow / Cloning / Evolution / Genomes / Leukemia / Mutation

2012

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Clonal evolution in relapsed acutemyeloid leukaemia revealed by whole-genome sequencing

in Bone marrow / Cloning / Evolution / Genomes / Leukemia / Mutation

2012

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Clonal evolution in relapsed acutemyeloid leukaemia revealed by whole-genome sequencing

in Bone marrow / Cloning / Evolution / Genomes / Leukemia / Mutation

2012

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Journal Article

Clonal evolution in relapsed acutemyeloid leukaemia revealed by whole-genome sequencing

Tomasson, Michael H,

Shannon, William D,

Wilson, Richard K,

Lu, Charles,

Kalicki-Veizer, Joelle,

McLellan, Michael D,

Mardis, Elaine R,

Lamprecht, Tamara,

Westervelt, Peter,

DiPersio, John F,

Link, Daniel C,

Fulton, Robert S,

Payton, Jacqueline E,

Ding, Li,

Ritchey, Julie K,

Larson, David E,

Heath, Sharon,

Fulton, Lucinda L,

Watson, Mark A,

McGrath, Sean D,

Kulkarni, Shashikant,

Wendl, Michael C,

Welch, John S,

Magrini, Vincent J,

Shen, Dong,

Graubert, Timothy A,

Walter, Matthew J,

Wallis, John W,

Ley, Timothy J,

Young, Margaret A,

McMichael, Joshua F,

Dooling, David J,

Cook, Lisa,

Vickery, Tammi L,

Chen, Ken,

Miller, Christopher A,

Harris, Christopher C,

Koboldt, Daniel C,

Schmidt, Heather

2012

Overview

To investigate the genetic changes associated withAML relapse, and to determine whether clonal evolution contributes to relapse, we performed whole-genome sequencing of primary tumour-relapse pairs andmatched skin samples fromeight patients, including unique patient identifier (UPN) 933124, whose primary tumourmutations were previously reported3. Assuming that all the mutations detected are heterozygous in the primary tumour sample (with a malignant cellular content at 93.72% for the primary bone marrow sample, see Supplementary Information), we were able to calculate the fraction of total malignant cells in each clone.

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Publisher

Nature Publishing Group

Subject

/ Cloning

/ Genomes