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Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix super( registered ) Targeted Genotyping System
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Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix super( registered ) Targeted Genotyping System
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Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix super( registered ) Targeted Genotyping System
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Journal Article
Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix super( registered ) Targeted Genotyping System
2007
Overview
The combined effects of multiple polymorphisms in several drug-metabolizing enzyme and transporter genes can contribute to considerable interindividual variation in drug disposition and response. Therefore, it has been of increasing interest to generate scalable, flexible and cost-effective technologies for large-scale genotyping of the drug-metabolizing enzyme and transporter genes. However, the number of drug-metabolizing enzyme and transporter gene variants exceeds the capacity of current technologies to comprehensively assess multiple polymorphisms in a single, multiplexed assay. The Targeted Genotyping System (Affymetrix super( registered ), CA, USA) provides a solution to this challenge, by combining molecular inversion probe technology with universal microarrays to provide a method that is capable of analyzing thousands of variants in a single reaction, while remaining relatively insensitive to cross-reactivity between reaction components. This review will focus on the Targeted Genotyping System and how this technology was adapted to enable comprehensive analysis of drug-metabolizing enzyme and transporter gene polymorphisms.
