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Vesicle-formation of hexadecyl phosphatidyl choline released from Im-caprolactone electrospun fibrous mats: preparation and characterization
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Vesicle-formation of hexadecyl phosphatidyl choline released from Im-caprolactone electrospun fibrous mats: preparation and characterization
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Journal Article
Vesicle-formation of hexadecyl phosphatidyl choline released from Im-caprolactone electrospun fibrous mats: preparation and characterization
2013
Overview
After it was proved by transmission electron microscope and light microscope that hexadecyl phosphatidyl choline (HePC) itself and HePC/cholesterol (Chol) complexes could form micro- or nanoscale vesicles, it was also found that vesicles composed by HePC itself or HePC/Chol could be formed by releasing from the fibers after electrospun poly Im-caprolactone (PCL) fibers with hexadecyl phosphatidyl choline (HePC) and Chol entrapped was obtained. Characterization by field emission scanning electron microscope, wide-angle X-ray diffraction, and differential thermal analysis indicated that HePC and HePC/Chol was perfectly entrapped in fibers. Beside these, it is was also found that HePC and Chol presented synchronous sustained release pattern from PCL by high-performance liquid chromatography. This experiment provided a further vision of composite materials composed of macromolecule and small molecule, for application in gene delivery, controlled drug delivery and bio-scaffold.
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