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Study Reveals Mechanism Involved in Neuropathic Pain and Could Help Develop Specific Treatment
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Newspaper Article
Study Reveals Mechanism Involved in Neuropathic Pain and Could Help Develop Specific Treatment
2023
Overview
[...]after a decade of research, a group of Brazilian scientists has succeeded in describing a mechanism associated with the production of neuropathic pain, opening up a new stage of their exploration in search of drugs that can act on the metabolic pathway in question and pointing to an avenue for the development of targeted therapies. According to Mattar Cunha, the discovery has opened up a hitherto unexplored field of research into the role of the meninges in the production of pain. Inflammation Previous research had already shown that the kynurenine pathway, whose formation depends on several enzymes but primarily on IDO1, is involved in pain. Because IDO1 is induced during pathological processes, especially inflammation, by pro-inflammatory cytokines, the researchers hypothesized that the neuroinflammation that causes neuropathic pain could increase IDO, raising the levels of these neurotoxic or neurostimulatory metabolites.
Publisher
Anthem Media Group
Subject
