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COVID-19–Associated Multisystem Inflammatory Syndrome in Children - United States, March–July 2020

by Pierce, Timmy , Leung, Jessica , Wallace, Bailey , Belay, Ermias , Roguski, Katherine , Conklin, Laura , Morris, Sapna Bamrah , Koumans, Emilia H , Feder, Kenneth A , Plipat, Nottasorn , Clarke, Kevin , Lash, Maura K , Hsu, Katherine K , Lee, Ellen H , Reilly, Kathleen H , Bryant, Bobbi , Oster, Matthew E , Hrapcak, Susan , Geevarughese, Anita , Abrams, Joseph , Thomas, Deepam , Lim, Sarah , Richardson, Gillian , Schmitz, Ann , Godfred-Cato, Shana , Prezzato, Emily , Pulver, Wendy P , Reid, Heather , Datta, Deblina

in Abdomen / Adolescents / Aneurysms / Children / Coronary vessels / Coronaviruses / COVID-19 / Fatalities / Gastrointestinal symptoms / Health care / Health care industry / Health services / Hispanic Americans / Illnesses / Inflammation / Kawasaki disease / Laboratory tests / Medical diagnosis / Medical laboratories / Medical personnel / Multisystem inflammatory syndrome in children / Pain / Pandemics / Patients / Pneumonia / Polymerase chain reaction / Serology / Severe acute respiratory syndrome / Severe acute respiratory syndrome coronavirus 2 / Tests / Viral diseases

2020

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2020

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COVID-19–Associated Multisystem Inflammatory Syndrome in Children - United States, March–July 2020

Pierce, Timmy,

Leung, Jessica,

Wallace, Bailey,

Belay, Ermias,

Roguski, Katherine,

Conklin, Laura,

Morris, Sapna Bamrah,

Koumans, Emilia H,

Feder, Kenneth A,

Plipat, Nottasorn,

Clarke, Kevin,

Lash, Maura K,

Hsu, Katherine K,

Lee, Ellen H,

Reilly, Kathleen H,

Bryant, Bobbi,

Oster, Matthew E,

Hrapcak, Susan,

Geevarughese, Anita,

Abrams, Joseph,

Thomas, Deepam,

Lim, Sarah,

Richardson, Gillian,

Schmitz, Ann,

Godfred-Cato, Shana,

Prezzato, Emily,

Pulver, Wendy P,

Reid, Heather,

Datta, Deblina

2020

Overview

Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe condition that has been reported approximately 2-4 weeks after the onset of COVID-19 in children and adolescents. Most cases of MIS-C have features of shock, with cardiac involvement, gastrointestinal symptoms, and significantly elevated markers of inflammation, with positive laboratory test results for SARS-CoV-2. Of the 565 patients who underwent SARS-CoV-2 testing, all had a positive test result by RT-PCR or serology. Distinguishing MIS-C from other severe infectious or inflammatory conditions poses a challenge to clinicians caring for children and adolescents. As the COVID-19 pandemic continues to expand in many jurisdictions, health care provider awareness of MIS-C will facilitate early recognition, early diagnosis, and prompt treatment.

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U.S. Center for Disease Control

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