Asset Details
Do you wish to reserve the book?
Distinguishing Human Peripheral Blood NK Cells from CD56 dim CD16 dim CD69 + CD103 + Resident Nasal Mucosal Lavage Fluid Cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Distinguishing Human Peripheral Blood NK Cells from CD56 dim CD16 dim CD69 + CD103 + Resident Nasal Mucosal Lavage Fluid Cells
Do you wish to request the book?
Distinguishing Human Peripheral Blood NK Cells from CD56 dim CD16 dim CD69 + CD103 + Resident Nasal Mucosal Lavage Fluid Cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Distinguishing Human Peripheral Blood NK Cells from CD56 dim CD16 dim CD69 + CD103 + Resident Nasal Mucosal Lavage Fluid Cells
2018
Overview
Natural killer (NK) cells are members of the innate lymphoid cells group 1 (ILC1s), which play a critical role in innate host defense against viruses and malignancies. While many studies have examined the role of circulating peripheral blood (PB) CD56
NK cells, little is known about the resident CD56
cell population. Therefore, matched CD56
cells from nasal lavage fluid (NLF) and PB of smokers and non-smokers were compared phenotypically, via flow cytometry, and functionally, via NK-cell specific gene expression. NLF and PB CD56
cells had similar expression of CD56, but differentially expressed tissue residency (CD69 and CD103) and cytotoxicity (CD16) markers. In addition, NLF CD56
cells expressed lower levels of cytotoxicity-associated genes, perforin (PRF1) and granzyme B (GZMB), and increased levels of cytokines and cell signaling molecules, TRAIL, IFNGR2, and IL8, as compared to PB CD56
cells. In smokers, ITGA2 was downregulated in NLF CD56
cells, while markers of cytotoxic function were primarily downregulated in PB CD56
NK cells. Overall, NLF CD56
cells are a unique cell population that likely play a role in orchestrating innate immune responses in the nasal cavity, which is distinct from their role as a non-antigen-restricted cytotoxic CD56
lymphocytes in the PB.
