Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Rapid expansion and international spread of M1 UK in the post-pandemic UK upsurge of Streptococcus pyogenes

by Coelho, Juliana , Didelot, Xavier , Vieira, Ana , Brown, Colin S , Razaei, Maryam , Croucher, Nicholas J , Jauneikaite, Elita , Mills, Ewurabena A , Wan, Yu , Reeves, Lucy C , Broughton, Karen , Soo, Valerie W C , Guy, Rebecca L , Harley, Alessandra , Daniel, Roger , Mok, Kai Yi , Mumin, Zaynab , Ganner, Marjorie A , Li, Ho Kwong , Mammadov, Rufat , Papangeli, Maria , Huse, Kristin K , Ganner, Mark , Rundberg, Emma , Sgro, Vincenzo , Lamagni, Theresa , Ryan, Yan , Dhami, Chenchal , Sriskandan, Shiranee

in Bacterial Proteins / COVID-19 - epidemiology / Europe - epidemiology / Genome, Bacterial / Humans / Mutation / Pandemics / Phylogeny / Repressor Proteins - genetics / SARS-CoV-2 - genetics / SARS-CoV-2 - isolation & purification / Scarlet Fever - epidemiology / Scarlet Fever - microbiology / Streptococcal Infections - epidemiology / Streptococcal Infections - microbiology / Streptococcus pyogenes - genetics / Streptococcus pyogenes - isolation & purification / Streptococcus pyogenes - pathogenicity / United Kingdom - epidemiology

2024

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Rapid expansion and international spread of M1 UK in the post-pandemic UK upsurge of Streptococcus pyogenes

2024

Confirm

Do you wish to request the book?

Rapid expansion and international spread of M1 UK in the post-pandemic UK upsurge of Streptococcus pyogenes

2024

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Rapid expansion and international spread of M1 UK in the post-pandemic UK upsurge of Streptococcus pyogenes

Coelho, Juliana,

Didelot, Xavier,

Vieira, Ana,

Brown, Colin S,

Razaei, Maryam,

Croucher, Nicholas J,

Jauneikaite, Elita,

Mills, Ewurabena A,

Wan, Yu,

Reeves, Lucy C,

Broughton, Karen,

Soo, Valerie W C,

Guy, Rebecca L,

Harley, Alessandra,

Daniel, Roger,

Mok, Kai Yi,

Mumin, Zaynab,

Ganner, Marjorie A,

Li, Ho Kwong,

Mammadov, Rufat,

Papangeli, Maria,

Huse, Kristin K,

Ganner, Mark,

Rundberg, Emma,

Sgro, Vincenzo,

Lamagni, Theresa,

Ryan, Yan,

Dhami, Chenchal,

Sriskandan, Shiranee

2024

Overview

The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage M1 to be the dominant source of invasive infections in this upsurge. Compared with ancestral M1 strains, invasive M1 strains exhibit reduced genomic diversity and fewer mutations in two-component regulator genes covRS. The emergence of M1 is dated to 2008. Following a bottleneck coinciding with the COVID-19 pandemic, three emergent M1 clades underwent rapid nationwide expansion, despite lack of detection in previous years. All M1 isolates thus-far sequenced globally have a phylogenetic origin in the UK, with dispersal of the new clades in Europe. While waning immunity may promote streptococcal epidemics, the genetic features of M1 point to a fitness advantage in pathogenicity, and a striking ability to persist through population bottlenecks.

Share this book

Add to My Shelf

Subject

Bacterial Proteins

/ COVID-19 - epidemiology

/ Europe - epidemiology

/ Humans

/ Repressor Proteins - genetics