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A marker for Stevens–Johnson syndrome
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Journal Article
A marker for Stevens–Johnson syndrome
2004
Overview
Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication
1
,
2
,
3
. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen
HLA–B
*
1502
, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens–Johnson syndrome.
Publisher
Nature Publishing Group UK
