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Small stress changes such as those from sea level fluctuations can be large enough to trigger earthquakes. If small and large earthquakes initiate similarly, high‐resolution catalogs with low detection thresholds are best suited to illuminate such processes. Below the Sea of Marmara section of the North Anatolian Fault, a segment of ≈$\\approx $ 150 km is late in its seismic cycle. We generated high‐resolution seismicity catalogs for a hydrothermal region in the eastern Sea of Marmara employing AI‐based and template matching techniques to investigate the link between sea level fluctuations and seismicity over 6 months. All high resolution catalogs show that local seismicity rates are larger during time periods shortly after local minima of sea level, when it is already rising. Local strainmeters indicate that seismicity is promoted when the ratio of differential to areal strain is the largest. The strain changes from sea level variations, on the order of 30–300 nstrain, are sufficient to promote seismicity. Plain Language Summary Quasi‐periodic phenomena are a natural probe to test how the Earth's responses to a certain stress perturbation. High‐resolution catalogs with low detection thresholds may provide a new opportunity to look for this type of earthquake triggering. A segment of 150 km below the Sea of Marmara section of the North Anatolian Fault is late in its seismic cycle. Here, we generated high‐resolution seismicity catalogs for 6 months covering a hydrothermal region south of Istanbul in the eastern Sea of Marmara including seismicity up to MW 4.5. For first time in this region, we document a strong effect of the Sea of Marmara water level changes on the local seismicity. Both high‐resolution catalogs show that local seismicity rates are significantly larger during time periods shortly after local minima on sea level, when the sea level is rising. The available local instrumentation provided an estimate of the strain changes that were sufficient to promote seismicity. If such small stress perturbations from sea level changes are enough to trigger seismicity, it may suggest that the region is very close to failure. Key Points We generated enhanced seismicity catalogs to investigate the potential link between sea level change and seismicity in a hydrothermal region Higher seismicity rates from the entire and declustered catalogs are observed during time periods when sea level is rising Strain estimates from local strainmeters show that seismicity was promoted during reduced normal and enhanced shear strain conditions

Numerous normal‐faulting aftershocks in subduction forearcs commonly follow large megathrust earthquakes. Postseismic normal faulting has been explained by stress changes induced by the stress drop along the megathrust. However, details of forearc stress changes and aftershock triggering mechanisms remain poorly understood. Here, we use numerical force‐balance models combined with Coulomb failure analysis to show that the megathrust stress drop supports normal faulting, but that forearc‐wide aftershock triggering is feasible within a narrow range of megathrust stress drop values and preseismic stress states only. We determine this range for the 2011 Tohoku earthquake (Japan) and show that the associated stress changes explain the aftershock seismicity in unprecedented detail and are consistent with the stress released by forearc seismicity before and after the earthquake. Plain Language Summary Earthquakes release stresses that build up in the Earth due to the motion of tectonic plates. The stress release can cause additional earthquakes called aftershocks. Several thousand onshore and offshore aftershocks followed the great Tohoku subduction earthquake in March 2011. Whether the stress release of the Tohoku earthquake triggered most of the aftershocks is not well understood, because it is largely unknown how the stress field changed following the earthquake. We therefore use a computer model to estimate the stress release and resulting stress change required to explain the aftershock distribution. We find that 78% of the aftershocks occurred in areas where the Tohoku earthquake caused a subsequent stress increase. Our model results are further consistent with the stress release of smaller earthquakes that occurred in Japan before and after the Tohoku earthquake. Our findings provide new insights into aftershock triggering and help to understand where aftershocks occur after great earthquakes at subduction zones. Key Points We show using force‐balance modeling that a megathrust earthquake stress drop can trigger forearc‐wide aftershock seismicity Model results explain the Tohoku earthquake aftershock distribution and reveal spatial variability in forearc stress and strength Most aftershocks occurred in areas that experienced an increase in deviatoric stress

Aftershocks of megathrust earthquakes at subduction zones may be driven by stresses arising from the topography of the forearc. However, the effect of topographic stresses on aftershock triggering is quantitatively not well understood and has been neglected in Coulomb failure stress models that assess whether the stress change caused by an earthquake promotes or inhibits failure on nearby faults. Here we use analytical and numerical models to examine the importance of topographic stresses on Coulomb failure stress changes caused by megathrust earthquakes. We show that topographic stresses are a prerequisite for widespread aftershock seismicity in the forearc and that their superposition with tectonic stresses leads to a dependence of the forearc stability on the stress state before and after the earthquake. The dependence can be taken into account by determining the Coulomb failure stress change between optimal failure planes before and after the earthquake, which requires constraining the total stresses in the forearc. Applying our modelling approach to the 2011 Mw 9.0 Tohoku-Oki and 2010 Mw 8.8 Maule megathrust earthquakes yields coseismic Coulomb failure stress changes of up to ∼40 MPa, which promoted the majority of aftershocks in the Japanese and Chilean forearcs. The model results further reveal that the spatial distribution of aftershocks was not only influenced by the megathrust stress drop and the proximity of faults to failure but also by local differences in forearc topography and pre-earthquake stress state. Our analysis highlights the significance of total stresses in Coulomb failure stress calculations, enabling a better estimation of seismic hazard at subduction zones.

By using two separate components, mem-sensing devices can be fabricated combining the sensitivity of a transducer with non-volatile memory. Here, we discuss how a mem-sensor can be fabricated using a single material with built- in sensing andmemory capabilities, based on ZnO microwires （MWs） embedded in a photocurable resin and processed from liquid by vertically aligning the MWs across the polymeric matrix using dielectrophoresis. This results in an ultraviolet （UV） photodetector, a device telecommunication, health, and defense, that is widely applied in fields such as and has so far implemented using bulk inorganic semiconductors. However, inorganic detectors suffer from very high production costs, brittleness, huge equipment requirements, and low responsivity. Here, we propose for the first time aneasy processable, reproducible, and low- cost hybrid UV mem-sensor. Composites with aligned ZnO MWs produce giant photocurrentscompared to the same composites with randomly distributed MWs. In particular, we efficiently exploit a mere-response where the photocurrent carries memory of the last electronic state experienced by the device when under testing. Furthermore, we demonstrate the non-equivalence of different wave profiles used during thedielectrophoresis： a pulsed wave is able to induce order in both the axis and the orientation of the MWs, whereas a sine wave only affects the orientation.

This phase 3, placebo-controlled platform trial evaluated a single infusion of casirivimab and imdevimab (REGEN-COV) at 2400-mg and 1200-mg doses in outpatients with acute SARS-CoV-2 infection. The incidence of Covid-19–related hospitalization was lower and recovery was faster among patients who received the antibody combination than among those who received placebo.

Cytomegalovirus is an important cause of disease in the newborn. The authors report data from a randomized trial of an extension of valganciclovir therapy from 6 weeks to 6 months for symptomatic CMV disease in newborns. Congenital cytomegalovirus (CMV) infection is the leading nongenetic cause of sensorineural hearing loss 1 – 4 and is the most frequent known viral cause of mental retardation 5 ; the infection affects 0.6 to 0.7% of live births in industrialized countries. 6 – 8 A total of 10% of congenitally infected neonates have symptomatic disease at birth, of whom 35% have sensorineural hearing loss, up to two thirds have neurologic deficits, and 4% die during the newborn period. 7 – 11 Although congenital CMV infection is rare overall, it accounts for 21% of children with hearing loss at birth and 24% of those with hearing loss at . . .

Whole genome duplication (WGD) is a powerful evolutionary mechanism in plants. Autopolyploids have been comparatively less studied than allopolyploids, with sexual autopolyploidization receiving even less attention. In this work, we studied the transcriptomes of neotetraploids (2n = 4x = 32) obtained by crossing two diploid (2n = 2x = 16) plants of Medicago sativa that produce a significant percentage of either 2n eggs or pollen. Diploid progeny from the same cross allowed us to separate the transcriptional outcomes of hybridization from those of WGD. This material can help to elucidate events at the base of the domestication of cultivated 4x alfalfa, the world’s most important leguminous forage. Three 2x and three 4x progeny plants and 2x parental plants were used for this study. The RNA-seq data revealed that WGD did not dramatically affect the transcription of leaf protein-coding genes. The two parental genotypes did not contribute equally to the progeny transcriptomes, and genome-wide expression level dominance of the male parent was observed. A large majority of the genes whose expression level changed due to WGD presented increased expression, indicating that the 4x state requires the upregulation of approximately 2.66% of the protein-coding genes. Overall, we estimated that 3.63% of the protein-coding genes were transcriptionally affected by WGD and may contribute to the phenotypic novelty of the neotetraploid plants. Pathway analysis suggested that WGD could affect secondary metabolite biosynthesis, which in turn may influence forage quality. We found four times as many transcription factor genes among the polyploidization-affected genes than among those affected only by hybridization. Several of these belong to classes involved in stress response. Small RNA-seq revealed that very few miRNAs were significantly associated with WGD, but they target several hundred genes, and their role in the WGD response may be relevant. Integrated network analysis led to the identification of putative miRNA: mRNA interactions potentially involved in transcriptome reprogramming. Allele-specific expression analysis indicated that parent-of-origin bias was not a significant outcome of WGD, but we found that parentally biased RNA editing may be a significant source of variation in neopolyploids.

Prader-Willi syndrome (PWS) is characterized by early-onset hyperphagia and increased circulating levels of the orexigenic Acylated Ghrelin (AG) hormone with a relative deficit of Unacylated Ghrelin (UAG). AZP-531, a first-in-class UAG analog, was shown to inhibit the orexigenic effect of AG in animals, to improve glycemic control and decrease body weight in humans. We aimed to investigate the safety and efficacy of AZP-531 in patients with PWS for whom no approved treatment for hyperphagia is currently available. Multi-center, randomized, double-blind, placebo-controlled trial. Forty-seven patients with genetically confirmed PWS and evidence of hyperphagia received daily subcutaneous injections of AZP-531 (3 and 4 mg for 50-70 kg and >70 kg body weight, respectively) or matching placebo for 14 days. Assessments included adverse events, vital signs, safety laboratory tests, the Hyperphagia Questionnaire (HQ), patient-reported appetite, body composition and glycemic measures. AZP-531 was well tolerated. There was a significant improvement with AZP-531 versus placebo in the mean total score, the 9-item score and the severity domain score of the HQ (p < .05). The highest reduction in the total and 9-item scores was observed in AZP-531 subjects with the highest hyperphagia score at baseline. Findings were supported by a reduction in appetite scores observed with AZP-531 only. Body weight did not change in both groups while a significant reduction in waist circumference and fat mass was observed only with AZP-531. AZP-531 significantly decreased post-prandial glucose levels in a baseline glucose dependent fashion. AZP-531 may constitute a new treatment strategy to improve hyperphagia and metabolic issues in patients with PWS. These findings support further investigation in longer-term clinical trials.

Cultivated olive, a typical fruit crop species of the semi-arid regions, could successfully face the new scenarios driven by the climate change through the selection of tolerant varieties to salt and drought stresses. In the present work, multidisciplinary approaches, including physiological, epigenetic and genetic studies, have been applied to clarify the salt tolerance mechanisms in olive. Four varieties (Koroneiki, Royal de Cazorla, Arbequina and Picual) and a related form ( O . europaea subsp. cuspidata ) were grown in a hydroponic system under different salt concentrations from zero to 200 mM. In order to verify the plant response under salt stress, photosynthesis, gas exchange and relative water content were measured at different time points, whereas chlorophyll and leaf concentration of Na + , K + and Ca 2+ ions, were quantified at 43 and 60 days after treatment, when stress symptoms became prominent. Methylation sensitive amplification polymorphism (MSAP) technique was used to assess the effects of salt stress on plant DNA methylation. Several fragments resulted differentially methylated among genotypes, treatments and time points. Real time quantitative PCR (RT-qPCR) analysis revealed significant expression changes related to plant response to salinity. Four genes ( OePIP1 . 1 , OePetD , OePI4Kg4 and OeXyla ) were identified, as well as multiple retrotransposon elements usually targeted by methylation under stress conditions.

Abstract Background The occurrence of spontaneous tumors in pet animals has been estimated in a few European and North American veterinary cancer registries with dissimilar methodologies and variable reference populations. Objectives The Animal Tumor Registry (ATR) of Genoa, Italy, was established in 1985 with the aim of estimating the occurrence of spontaneous tumors in dogs. Methods Six thousand seven hundred and forty-three tumor biopsy specimens were received from local veterinarians in the Municipality of Genoa between 1985 and 2002. Three thousand and three hundred and three (48.9%) biopsy specimen samples were diagnosed as cancer and were coded according to the International Statistical Classification of Diseases (ICD-9). Results Mammary cancer was the most frequently diagnosed cancer in female dogs, accounting for 70% of all cancer cases. Incidence of all cancers was 99.3 per 100,000 dog-years (95% CI: 93.6–105.1) in male dogs and 272.1 (95% CI: 260.7–283.6) in female dogs. The highest incidence rates were detected for mammary cancer (IR = 191.8, 95% CI: 182.2–201.4) and for non-Hodgkin's lymphoma (IR = 22.9, 95% CI: 19.7–26.5) in bitches and for non-Hodgkin's lymphoma (IR = 19.9, 95% CI: 17.4–22.7) and skin cancer (IR = 19.1, 95% CI: 16.6–21.8) in male dogs. All cancer IR increased with age ranging between 23.7 (95% CI: 18.4–30.1) and 763.2 (95% CI: 700.4–830.1) in bitches and between 16.5 (95% CI: 12.8–21.1) and 237.6 (95% CI: 209.1–269.0) in male dogs aged ≤3 years and >9–11 years. Conclusion This study summarizes the work done by the ATR of Genoa, Italy, between 1985 and 2002. All cancer incidence was 3 times higher in female than in male dogs, a difference explained by the high rate of mammary cancer observed in bitches. Because a biopsy specimen was required to make a cancer diagnosis, cancer rates for internal organs cancers, such as respiratory and digestive tract cancers may have been underestimated in the study population.