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REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

by Stahl, Neil , Baum, Alina , DiCioccio, A. Thomas , Norton, Thomas , Sivapalasingam, Sumathi , Roque-Guerrero, Lilia , Kampman, Wendy , Im, Joseph , Hamilton, Jennifer D , Bocchini, Joseph A , Davis, John D , Weinreich, David M , Gao, Haitao , Hosain, Romana , Atmodjo, Dominique Y , Aazami, Hessam , Lipsich, Leah , Ali, Shazia , Kyratsous, Christos A , Acloque, Gerard , Rofail, Diana , Hooper, Andrea T , Bhore, Rafia , Mahmood, Adnan , Cannon, Kevin , Kim, Yunji , Simón-Campos, J. Abraham , Pan, Cynthia , Geba, Gregory P , Musser, Bret J , Hussein, Mohamed , Herman, Gary , Xiao, Jing , Turner, Kenneth C , Kowal, Bari , Yancopoulos, George D , Cook, Amanda , Braunstein, Ned , Soo, Yuhwen , Perry, Christina

in Adolescent / Adult / Adverse events / Antibodies / Antibodies, Monoclonal, Humanized - administration & dosage / Antibodies, Monoclonal, Humanized - pharmacokinetics / Antibodies, Monoclonal, Humanized - pharmacology / Antibodies, Neutralizing - administration & dosage / Antibodies, Neutralizing - pharmacology / Antiviral Agents - administration & dosage / Antiviral Agents - pharmacokinetics / Antiviral Agents - pharmacology / Confidence intervals / Coronavirus / Coronaviruses / COVID-19 / COVID-19 - mortality / COVID-19 Drug Treatment / Death / Dose-Response Relationship, Drug / Double-Blind Method / Drug Combinations / Female / Hospitalization / Hospitalization - statistics & numerical data / Humans / Infectious Disease / Intravenous administration / Kaplan-Meier Estimate / Laboratories / Male / Middle Aged / Monoclonal antibodies / Original / Patients / Placebos / Pregnancy / Pregnancy Complications, Infectious - drug therapy / Proportional Hazards Models / Risk factors / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Viral Load - drug effects / Young Adult

2021

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REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

2021

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REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

2021

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Journal Article

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19

Stahl, Neil,

Baum, Alina,

DiCioccio, A. Thomas,

Norton, Thomas,

Sivapalasingam, Sumathi,

Roque-Guerrero, Lilia,

Kampman, Wendy,

Im, Joseph,

Hamilton, Jennifer D,

Bocchini, Joseph A,

Davis, John D,

Weinreich, David M,

Gao, Haitao,

Hosain, Romana,

Atmodjo, Dominique Y,

Aazami, Hessam,

Lipsich, Leah,

Ali, Shazia,

Kyratsous, Christos A,

Acloque, Gerard,

Rofail, Diana,

Hooper, Andrea T,

Bhore, Rafia,

Mahmood, Adnan,

Cannon, Kevin,

Kim, Yunji,

Simón-Campos, J. Abraham,

Pan, Cynthia,

Geba, Gregory P,

Musser, Bret J,

Hussein, Mohamed,

Herman, Gary,

Xiao, Jing,

Turner, Kenneth C,

Kowal, Bari,

Yancopoulos, George D,

Cook, Amanda,

Braunstein, Ned,

Soo, Yuhwen,

Perry, Christina

2021

Overview

This phase 3, placebo-controlled platform trial evaluated a single infusion of casirivimab and imdevimab (REGEN-COV) at 2400-mg and 1200-mg doses in outpatients with acute SARS-CoV-2 infection. The incidence of Covid-19–related hospitalization was lower and recovery was faster among patients who received the antibody combination than among those who received placebo.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Adverse events

/ Antibodies

/ Antibodies, Monoclonal, Humanized - administration & dosage

/ Antibodies, Monoclonal, Humanized - pharmacokinetics

/ Antibodies, Monoclonal, Humanized - pharmacology