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"Fu, Lu"
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Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis
Objective
This study aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) for infertility and recurrent spontaneous abortion.
Methods
Existing research was searched in PubMed, Embase and Cochrane Library till Dec 2021. Randomized control trials (RCTs) that compared G-CSF administration with the control group in infertility women undergoing IVF were included. The primary outcomes included clinical pregnancy rate; the secondary outcomes included live birth rate, abortion ratebiochemical pregnancy rate, embryo implantation rate, as well as endometrial thickness.
Result(s)
20 RCTs were included in this study. G-CSF increased the clinical pregnancy rate (RR = 1.85; 95% CI: 1.07, 3.18) and the endometrial thickness (MD = 2.25; 95% CI: 1.58,2.92;) in patients with thin endometrium undergoing IVF. G-CSF increased the biochemical pregnancy rate (RR = 2.12; 95% CI: 1.54, 2.93), the embryo implantation rate (RR = 2.51; 95% CI: 1.82, 3.47) and the clinical pregnancy rate (RR = 1.93; 95% CI: 1.63, 2.29) in patients with a history of repeated implantation failure undergoing IVF. No differences were found in pregnancy outcomes of general IVF patients.
Conclusions
Granulocyte colony-stimulating factor is likely to be a potential option for infertility women undergoing IVF with thin endometrium or recurrent implantation failure .
Trial registration
Retrospectively registered (The PROSPERO registration number: CRD42022360161).
Journal Article
Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19: a retrospective study
Background
COVID-19 is highly contagious, and the crude mortality rate could reach 49% in critical patients. Inflammation concerns on disease progression. This study analyzed blood inflammation indicators among mild, severe and critical patients, helping to identify severe or critical patients early.
Methods
In this cross-sectional study, 100 patients were included and divided into mild, severe or critical groups according to disease condition. Correlation of peripheral blood inflammation-related indicators with disease criticality was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.
Results
Significantly, disease severity was associated with age (
R
= -0.564,
P
< 0.001), interleukin-2 receptor (IL2R) (
R
= -0.534,
P
< 0.001), interleukin-6 (IL-6) (
R
= -0.535,
P
< 0.001), interleukin-8 (IL-8) (
R
= -0.308,
P
< 0.001), interleukin-10 (IL-10) (
R
= -0.422,
P
< 0.001), tumor necrosis factor α (TNFα) (
R
= -0.322,
P
< 0.001), C-reactive protein (CRP) (
R
= -0.604,
P
< 0.001), ferroprotein (
R
= -0.508,
P
< 0.001), procalcitonin (
R
= -0.650,
P
< 0.001), white cell counts (WBC) (
R
= -0.54,
P
< 0.001), lymphocyte counts (LC) (
R
= 0.56,
P
< 0.001), neutrophil count (NC) (
R
= -0.585,
P
< 0.001) and eosinophil counts (EC) (
R
= 0.299,
P
< 0.001). With IL2R > 793.5 U/mL or CRP > 30.7 ng/mL, the progress of COVID-19 to critical stage should be closely observed and possibly prevented.
Conclusions
Inflammation is closely related to severity of COVID-19, and IL-6 and TNFα might be promising therapeutic targets.
Journal Article
تاريخ العلاقات بين الصين وعمان
يستعرض هذا الكتاب الجوانب التاريخية والسياسية والثقافية للعلاقات بين الصين وسلطنة عمان، منذ العصور القديمة وحتى العصر الحديث، مع تركيز خاص على التبادل التجاري والبحري الذي ازدهر بين الجانبين عبر طريق الحرير البحري. يبرز الكتاب كيف شكل التواصل الحضاري بين الصين وعمان أحد أقدم النماذج للعلاقات السلمية في التاريخ، حيث ساهم البحارة العمانيون في نقل السلع والثقافات بين الشرق الأقصى والجزيرة العربية. كما يتناول العلاقات الدبلوماسية الحديثة بين البلدين، وتطورها في إطار الشراكات الاقتصادية ومبادرة الحزام والطريق، مؤكدا على الاحترام المتبادل والتعاون المتوازن بين البلدين عبر القرون.
BOOK
The apple MdCOP1-interacting protein 1 negatively regulates hypocotyl elongation and anthocyanin biosynthesis
Background
In plants, CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) is a key negative regulator in photoperiod response. However, the biological function of COP1-interacting protein 1 (CIP1) and the regulatory mechanism of the CIP1-COP1 interaction are not fully understood.
Results
Here, we identified the apple
MdCIP1
gene based on the Arabidopsis
AtCIP1
gene. Expression pattern analysis showed that
MdCIP1
was constitutively expressed in various tissues of apple, and responded to stress and hormone signals at the transcriptional level. Ectopic expression of
MdCIP1
complemented the phenotypes of the Arabidopsis
cip1
mutant, and MdCIP1 inhibited anthocyanin biosynthesis in apple calli. In addition, the biochemical assay demonstrated that MdCIP1 could interact with MdCOP1 protein by their coiled-coil domain, and
MdCIP1-OX/cop1–4
had a similar phenotype in photomorphogenesis with the
cop1–4
mutant, suggesting that
COP1
is epistatic to
CIP1
. Furthermore, the transient transformation assay indicated that MdCIP1 repressed anthocyanin biosynthesis in an MdCOP1-mediated pathway.
Conclusion
Take together, this study finds that MdCIP1 acts as a repressor in regulating hypocotyl elongation and anthocyanin biosynthesis through MdCOP1 in apple.
Journal Article
Recurrent Neural Network Methods for Extracting Dynamic Balance Variables during Gait from a Single Inertial Measurement Unit
Monitoring dynamic balance during gait is critical for fall prevention in the elderly. The current study aimed to develop recurrent neural network models for extracting balance variables from a single inertial measurement unit (IMU) placed on the sacrum during walking. Thirteen healthy young and thirteen healthy older adults wore the IMU during walking and the ground truth of the inclination angles (IA) of the center of pressure to the center of mass vector and their rates of changes (RCIA) were measured simultaneously. The IA, RCIA, and IMU data were used to train four models (uni-LSTM, bi-LSTM, uni-GRU, and bi-GRU), with 10% of the data reserved to evaluate the model errors in terms of the root-mean-squared errors (RMSEs) and percentage relative RMSEs (rRMSEs). Independent t-tests were used for between-group comparisons. The sensitivity, specificity, and Pearson’s r for the effect sizes between the model-predicted data and experimental ground truth were also obtained. The bi-GRU with the weighted MSE model was found to have the highest prediction accuracy, computational efficiency, and the best ability in identifying statistical between-group differences when compared with the ground truth, which would be the best choice for the prolonged real-life monitoring of gait balance for fall risk management in the elderly.
Journal Article
Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination
Background
Epigenetic regulation by histone deacetylases (HDACs) in Schwann cells (SCs) after injury facilitates them to undergo de- and redifferentiation processes necessary to support various stages of nerve repair. Although de-differentiation activates the synthesis and secretion of inflammatory cytokines by SCs to initiate an immune response during nerve repair, changes in either the timing or duration of prolonged inflammation mediated by SCs can affect later processes associated with repair and regeneration. Limited studies have investigated the regulatory processes through which HDACs in SCs control inflammatory cytokines to provide a favorable environment for peripheral nerve regeneration.
Methods
We employed the HDAC inhibitor (HDACi) sodium phenylbutyrate (PBA) to address this question in an in vitro RT4 SC inflammation model and an in vivo sciatic nerve transection injury model to examine the effects of HDAC inhibition on the expression of pro-inflammatory cytokines. Furthermore, we assessed the outcomes of suppression of extended inflammation on the regenerative potential of nerves by assessing axonal regeneration, remyelination, and reinnervation.
Results
Significant reductions in lipopolysaccharide (LPS)-induced pro-inflammatory cytokine (tumor necrosis factor-α [TNFα]) expression and secretion were observed in vitro following PBA treatment. PBA treatment also affected the transient changes in nuclear factor κB (NFκB)-p65 phosphorylation and translocation in response to LPS induction in RT4 SCs. Similarly, PBA mediated long-term suppressive effects on HDAC3 expression and activity. PBA administration resulted in marked inhibition of pro-inflammatory cytokine secretion at the site of transection injury when compared with that in the hydrogel control group at 6-week post-injury. A conducive microenvironment for axonal regrowth and remyelination was generated by increasing expression levels of protein gene product 9.5 (PGP9.5) and myelin basic protein (MBP) in regenerating nerve tissues. PBA administration increased the relative gastrocnemius muscle weight percentage and maintained the intactness of muscle bundles when compared with those in the hydrogel control group.
Conclusions
Suppressing the lengthened state of inflammation using PBA treatment favors axonal regrowth and remyelination following nerve transection injury. PBA treatment also regulates pro-inflammatory cytokine expression by inhibiting the transcriptional activation of NFκB-p65 and HDAC3 in SCs in vitro.
Journal Article
Motivations and Strategies of Sport-Based Corporate Social Responsibility: Multiple Case Studies of Taiwanese Enterprises
Since the United Nations announced the 2030 Agenda for Sustainable Development in 2015, which includes 17 Sustainable Development Goals (SDGs) guiding global efforts from 2016 to 2030, corporate organizations have increasingly integrated SDGs into their cultures, adopting innovative strategies to practice sustainable development. This integration has yielded numerous inspiring breakthroughs and success stories. Corporate organizations have found significant contemporary relevance in practicing corporate social responsibility (CSR) through sports. This study explores the motivations for and the scope of CSR activities undertaken by Taiwanese enterprises that use sports as a vehicle. Through in-depth interviews and multiple case studies, this study examines the commonalities and uniqueness of sport-based CSR, providing a detailed depiction of the current state and challenges faced by enterprises engaging in sport-based CSR and sustainable development. The findings will lead to new perspectives and feasible strategic directions for the advancement of sport-based CSR.
Journal Article
Enhancing university student employability through practical experiential learning in the sport industry: An industry-academia cooperation case from Taiwan
The purpose of this study is to develop an industry-academia strategy to help undergraduate sport management students enhance employability through practical experiential learning in a specific sporting event. Both in-depth interviews and a questionnaire survey were administered to teachers, enterprise mentors and students to evaluate students’ learning outcomes and reveal how embedding PEL into a professional course could enhance employability. The results not only identify the necessary employability skills, attitudes, and traits that students should possess before graduation, but also address the benefits of incorporating PEL into professional curriculum through practicing the learning-by-doing philosophy.
•The findings illustrate the relationship between practical experiential learning and student employability.•The study identifies the necessary skills, attitudes, and traits that students should possess before graduation.•Provide useful advice of employability enhancement from mentors and teachers.•Address the benefits of incorporating PEL into professional curriculum for college students.
Journal Article