Journal Article

Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis

Xu, Ying, Fu, Lu-lu, Zhang, Xue-ying, Li, Dan-dan, Zheng, Lian-wen, Yan, Jing

2023

Overview

Objective This study aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) for infertility and recurrent spontaneous abortion. Methods Existing research was searched in PubMed, Embase and Cochrane Library till Dec 2021. Randomized control trials (RCTs) that compared G-CSF administration with the control group in infertility women undergoing IVF were included. The primary outcomes included clinical pregnancy rate; the secondary outcomes included live birth rate, abortion ratebiochemical pregnancy rate, embryo implantation rate, as well as endometrial thickness. Result(s) 20 RCTs were included in this study. G-CSF increased the clinical pregnancy rate (RR = 1.85; 95% CI: 1.07, 3.18) and the endometrial thickness (MD = 2.25; 95% CI: 1.58,2.92;) in patients with thin endometrium undergoing IVF. G-CSF increased the biochemical pregnancy rate (RR = 2.12; 95% CI: 1.54, 2.93), the embryo implantation rate (RR = 2.51; 95% CI: 1.82, 3.47) and the clinical pregnancy rate (RR = 1.93; 95% CI: 1.63, 2.29) in patients with a history of repeated implantation failure undergoing IVF. No differences were found in pregnancy outcomes of general IVF patients. Conclusions Granulocyte colony-stimulating factor is likely to be a potential option for infertility women undergoing IVF with thin endometrium or recurrent implantation failure . Trial registration Retrospectively registered (The PROSPERO registration number: CRD42022360161).

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Abortion / Abortion, Habitual / Analysis / Bias / Birth rate / Bone marrow / Care and treatment / Clinical trials / Colonies / Colony-stimulating factor / current development and its future / Diagnosis / Embryos / Endocrinology / Endometrium / Female / Fertilization in Vitro / Glycoproteins / Granulocyte colony-stimulating factor / Granulocyte Colony-Stimulating Factor - therapeutic use / Granulocytes / Humans / Implantation / In vitro fertilization / Infertility / Infertility, Female - therapy / IVF / IVF – the past / Leukocytes (granulocytic) / Live Birth / Medicine / Medicine & Public Health / Meta-analysis / Miscarriage / Patient outcomes / Pregnancy / Pregnancy Outcome / Pregnancy Rate / Prevention / Recurrent spontaneous abortion / Repeated implantation failure / Reproductive Medicine / Review / Risk factors / Thin endometrium