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"Huang, Fuhua"
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A history of Chinese martial arts
\"Chinese martial arts have a long, meaningful history and deep cultural roots. They blend the physical components of combat with strategy, philosophy and tradition, distinguishing them from Western sports. A History of Chinese Martial Arts is the most authoritative study ever written on this topic, featuring contributions from leading Chinese scholars and practitioners. The book provides a comprehensive overview of all types of Chinese martial arts, from the Pre-Qin Period (before 222 BC) right up to the present day in the People's Republic of China, with each chapter covering a different period in Chinese history. Including numerous illustrations of artefacts, weaponry and historical drawings and documents, this book offers unparalleled insight into the origins, development and contemporary significance of martial arts in China. This is a fascinating read for researchers and students working in sports history, Chinese sport and Chinese Studies\"-- Provided by publisher.
Book
Self-growth of programmable 2D- and 3D-coupling responsive coating for anti-counterfeiting
Programmable dual-mode (two- or three- dimension, 2D/3D)-coupling responsive coating constitutes one of the most promising strategies to ensure the security of anti-counterfeiting and information encryption, but it is still lack of effective approaches to integrate stimuli-responsive 2D and 3D information. Herein, we develop a self-growing method to achieve this purpose based on photoswitchable fluorescence and supramolecular interaction (dipole-dipole interaction) toward advanced multi-dimensional anti-counterfeiting and encryption. In our method, trifluoromethyl-rich monomers (2,2,2-trifluoroethyl methacrylate (TFEMA) and 2,2,3,4,4,4-hexafluorobutyl acrylate (HFBA)), polymerizable green fluorescent dye (2-(6-(dimethylamino)−1,3-dioxo- 1H-benzodeisoquinolin-2(3H)-yl) ethyl acrylate, MNEA) and photochromic diarylethene derivative (4-(acryloyloxy) butyl-4-(2-methyl-3-(2-(2-methylbenzo thiophen-3-yl)−4-oxo-5,6-dihydro-4H-thieno 2,3- thiopyran-3-yl) benzo thiophen-6-yl)−4-oxobutanoate, BTBA) are introduced into specific 3D structure via a self-growing method. The coating is capable of reversible fluorescence switching from green to red through photo-induced fluorescence resonance energy transfer (FRET) process between MNEA and BTBA, and reversible switch of 3D structure based on force- and thermo-induced shape memory caused by dipole-dipole interaction and covalent bond. Interestingly, when the 2D information is stimulated, the 3D information remains unchanged. Several examples demonstrate that the great application potential of the programmable responsive coating in high-security of multilevel anti-counterfeiting and information encryption. We thus envision the great potential of our method in developing advanced anti-counterfeiting, multilevel information encryption and high-density data storage.
Programable coatings are promising for information encryption, though it is challenging to design stimuli-responsive materials. Here the authors integrate a photochromic switch into a polymer system for programmable encryption.
Journal Article
2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis
Background
Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15–19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Targeting the DDR process was considered a feasible strategy benefitting osteosarcoma patients. However, the clinical application of DDR inhibitors is not impressive because of their side effects. Chinese herbal medicines with high anti-tumor effects and low toxicity in the human body have gradually gained attention. 2-Hydroxy-3-methylanthraquinone (HMA), a Chinese medicine monomer found in the extract of Oldenlandia diffusa, exerts significant inhibitory effects on various tumors. However, its anti-osteosarcoma effects and defined molecular mechanisms have not been reported.
Methods
After HMA treatment, the proliferation and metastasis capacity of osteosarcoma cells was detected by CCK-8, colony formation, transwell assays and Annexin V-fluorescein isothiocyanate/propidium iodide staining. RNA-sequence, plasmid infection, RNA interference, Western blotting and immunofluorescence assay were used to investigate the molecular mechanism and effects of HMA inhibiting osteosarcoma. Rescue assay and CHIP assay was used to further verified the relationship between MYC, CHK1 and RAD51.
Results
HMA regulate MYC to inhibit osteosarcoma proliferation and DNA damage repair through PI3K/AKT signaling pathway. The results of RNA-seq, IHC, Western boltting etc. showed relationship between MYC, CHK1 and RAD51. Rescue assay and CHIP assay further verified HMA can impair homologous recombination repair through the MYC-CHK1-RAD51 pathway.
Conclusion
HMA significantly inhibits osteosarcoma proliferation and homologous recombination repair through the MYC-CHK1-RAD51 pathway, which is mediated by the PI3K-AKT signaling pathway. This study investigated the exact mechanism of the anti-osteosarcoma effect of HMA and provided a potential feasible strategy for the clinical treatment of human osteosarcoma.
Graphical Abstract
Journal Article
A novel nomogram model to predict in-hospital mortality in patients with acute type A aortic dissection after surgery
Background
Acute type A aortic dissection is a dangerous disease that threatens public health. In recent years, with the progress of medical technology, the mortality rate of patients after surgery has been gradually reduced, leading that previous prediction models may not be suitable for nowadays. Therefore, the present study aims to find new independent risk factors for predicting in-hospital mortality and construct a nomogram prediction model. Methods: The clinical data of 341 consecutive patients in our center from 2019 to 2023 were collected, and they were divided into two groups according to the death during hospitalization. The independent risk factors were analyzed by univariate and multivariate logistic regression, and the nomogram was constructed and verified based on these factors. Results: age, preoperative lower limb ischemia, preoperative
activated partial thromboplastin time (APTT)
, preoperative platelet count,
Cardiopulmonary bypass (CPB)
time and postoperative
acute kidney injury (AKI)
independently predicted in-hospital mortality of patients with acute type A aortic dissection after surgery. The
area under the receiver operating characteristic curve (AUC)
for the nomogram was 0.844. The calibration curve and decision curve analysis verified that the model had good quality. Conclusion: The new nomogram model has a good ability to predict the in-hospital mortality of patients with acute type A aortic dissection after surgery.
Journal Article
E-Skin and Its Advanced Applications in Ubiquitous Health Monitoring
E-skin is a bionic device with flexible and intelligent sensing ability that can mimic the touch, temperature, pressure, and other sensing functions of human skin. Because of its flexibility, breathability, biocompatibility, and other characteristics, it is widely used in health management, personalized medicine, disease prevention, and other pan-health fields. With the proposal of new sensing principles, the development of advanced functional materials, the development of microfabrication technology, and the integration of artificial intelligence and algorithms, e-skin has developed rapidly. This paper focuses on the characteristics, fundamentals, new principles, key technologies, and their specific applications in health management, exercise monitoring, emotion and heart monitoring, etc. that advanced e-skin needs to have in the healthcare field. In addition, its significance in infant and child care, elderly care, and assistive devices for the disabled is analyzed. Finally, the current challenges and future directions of the field are discussed. It is expected that this review will generate great interest and inspiration for the development and improvement of novel e-skins and advanced health monitoring systems.
Journal Article
Hybrid technique and total arch replacement combined with frozen elephant trunk in acute aortic dissection involving the aortic arch: a multi-center propensity-matched cohort study
Background
The aim of this study was to investigate whether the hybrid technique yields superior outcomes in comparison with the total arch replacement combined with frozen elephant trunk (TAR + FET) for acute aortic dissection (AAD) involving the aortic arch.
Methods
This retrospective cohort study using propensity-score matching included patients with AAD involving the aortic arch admitted to Nanjing First Hospital and Shanghai General Hospital from January 2015 to June 2020. The in-hospital and mid-term outcomes were compared between patients who received hybrid treatment (
n
= 136) and those who received TAR + FET (
n
= 415). Study end points included in-hospital mortality and morbidity, and mid-term rates of death from all causes, stroke, and aortic re-intervention.
Results
A total of 121 pairs were formed after matching. In-hospital mortality did not differ between hybrid versus TAR + FET groups (5.8% vs. 7.9%,
P
= .860). Up to 6 years, patients treated with TAR + FET were associated with reduced rate of aortic re-intervention (HR 0.21, 95% CI 0.05–0.97;
P
= .023). There was no difference in death from all causes and stroke.
Conclusions
Hybrid technique and TAR + FET showed comparable mid-term survival. Hybrid technique showed higher rate of aortic re-intervention and should therefore be applied with great caution in patients with AAD involving the aortic arch.
Journal Article
Research on Yarn Amount Control for PMSM in Yarn Feeder Based on Improved DSOGI and Kalman Filter
To solve the problems of rotor position estimation error caused by the installation deviation of Hall sensors and the increase in yarn amount detection error in complex environments, resulting in speed fluctuations and unstable yarn feeding in the traditional permanent magnet synchronous motor (PMSM) drive system for yarn feeder, a control method for yarn amount in yarn feeder PMSMs based on an improved dual second-order generalized integrator (DSOGI) and Kalman filter is proposed. Firstly, in order to reduce the influence of installation deviation of Hall sensors, the three-phase Hall signals are converted into two-phase orthogonal Hall vector signals. An improved DSOGI is used to filter out high-order harmonic components and specific harmonic components in the Hall vector signals, and a cross-coupled structure is constructed to further enhance the fundamental component and suppress high-order harmonic components of negative coefficients. Then, accurate motor rotor position information is extracted by a quadrature phase-locked loop; secondly, in order to obtain accurate information on yarn amount, a system state model based on yarn amount and its rate of change is established, and Kalman filtering is used for optimal estimation of the yarn amount; finally, the above methods are integrated into the PMSM control system of the yarn feeder. Experimental results show that, compared with traditional methods, the PMSM control system of the yarn feeder using the method proposed in this paper has a shorter startup time and smaller steady-state error in motor speed and yarn amount when conveying yarn at a constant speed; when transporting yarn at variable speed, the motor speed and yarn amount settling time are shorter, and the peak deviation is smaller.
Journal Article
The diameter of sinotubular junction to body surface area is independently associated with incident acute type a aortic dissection
Objective
The main aim of this study is to measure and calculate the ratio of sinotubular junction diameter to body surface area (RDA) in patients with acute type A aortic dissection (ATAAD) and normal subjects, and to analyze the relationship between RDA and ATAAD to provide guidance for primary prevention of ATAAD.
Methods
This retrospective observational study totally admitted consecutive 320 patients with acute type A aortic dissection diagnosed in Nanjing First Hospital from March 2017 to March 2021. Meanwhile, 608 healthy subjects who took echocardiography examination in outpatient was selected as controls. The diameter of sinotubular junction (D.STJ) was measured using echocardiography and direct vision (in some ATAAD patients). The differences in body surface area (BSA), D.STJ and RDA index in both groups were assessed. The association between D.STJ and demographic characteristics were established. RDA index was used to distinguish the ATAAD and healthy subjects.
Results
The diameter of STJ (24.41 ± 2.16 mm versus 26.66 ± 2.60 mm) and RDA index (13.16 ± 1.67 versus 15.40 ± 1.59) were significantly different between dissection group and control group. The D.STJ were found a positive, linear correlation to BSA in the healthy subjects. Multivariate logistic regression showed that RDA index was one of the independent risk factors to associated with ATAAD as a continuous variable (odds ratio (OR), 0.403, 95% confidence interval (CI): 0.352–0.457,
P
< 0.001) or a categorical variable (RDA cut-off: 13.88 mm/m
2
, OR, 0.070, 95%CI: 0.050–0.098,
P
< 0.001).
Conclusions
RDA index is an independent and key risk factor for ATAAD occurrence. Timely identification of high-risk patients using RDA index has the potential to become an optional guidance for primary prevention of ATAAD.
Journal Article
Macrophage, a potential targeted therapeutic immune cell for cardiomyopathy
Cardiomyopathy is a major cause of heart failure, leading to systolic and diastolic dysfunction and promoting adverse cardiac remodeling. Macrophages, as key immune cells of the heart, play a crucial role in inflammation and fibrosis. Moreover, exogenous and cardiac resident macrophages are functionally and phenotypically different during cardiac injury. Although experimental evidence has shown that macrophage-targeted therapy is promising in cardiomyopathy, clinical translation remains challenging. In this article, the molecular mechanism of macrophages in cardiomyopathy has been discussed in detail based on existing literature. The issues and considerations of clinical treatment strategies for myocardial fibrosis has also been analyzed.
Journal Article