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"Huang, Ting"
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The translation and transmission of concrete poetry
\"This volume unpacks the impact of the reception and translation of \"untranslatable\" experimental poetry on the growth of this global literary movement, influenced by the work of Ezra Pound and Ernest Fenollosa. Featuring contributions from an international group of literary and translation scholars and practitioners, working across a variety of languages, the book views the movement's development through the lens of \"transcreation\", framed here as the informed but creative process and response to difficult or untranslatable texts, and spotlights case studies from Ezra Pound and the Brazilian Noigrandre group, early modernism, and Chinese-language concrete poetry, while other chapters engage in discussions of social network analysis and examinations of 21st century concrete poetry to further demonstrate the significance of crosslinguistic contact in the translation process. Highlighting the myriad ways in which literary influence is mapped across languages and borders, this volume will be of interest to students and scholars in translation studies, experimental literature, poetry, and comparative literature\"-- Provided by publisher.
Book
Horizontal gene transfer and adaptive evolution in bacteria
Horizontal gene transfer (HGT) is arguably the most conspicuous feature of bacterial evolution. Evidence for HGT is found in most bacterial genomes. Although HGT can considerably alter bacterial genomes, not all transfer events may be biologically significant and may instead represent the outcome of an incessant evolutionary process that only occasionally has a beneficial purpose. When adaptive transfers occur, HGT and positive selection may result in specific, detectable signatures in genomes, such as gene-specific sweeps or increased transfer rates for genes that are ecologically relevant. In this Review, we first discuss the various mechanisms whereby HGT occurs, how the genetic signatures shape patterns of genomic variation and the distinct bioinformatic algorithms developed to detect these patterns. We then discuss the evolutionary theory behind HGT and positive selection in bacteria, and discuss the approaches developed over the past decade to detect transferred DNA that may be involved in adaptation to new environments.Bacterial DNA transfers between cells in numerous ways and becomes integrated into the genome, with diverse consequences for bacterial genomes. In this Review, Arnold, Huang and Hanage discuss the underlying theory used to infer the selective forces acting on transferred DNA and how they shape patterns of genomic variation.
Journal Article
Homopolish: a method for the removal of systematic errors in nanopore sequencing by homologous polishing
Nanopore sequencing has been widely used for the reconstruction of microbial genomes. Owing to higher error rates, errors on the genome are corrected via neural networks trained by Nanopore reads. However, the systematic errors usually remain uncorrected. This paper designs a model that is trained by homologous sequences for the correction of Nanopore systematic errors. The developed program, Homopolish, outperforms Medaka and HELEN in bacteria, viruses, fungi, and metagenomic datasets. When combined with Medaka/HELEN, the genome quality can exceed Q50 on R9.4 flow cells. We show that Nanopore-only sequencing can produce high-quality microbial genomes sufficient for downstream analysis.
Journal Article
A role for neutrophils in early enthesitis in spondyloarthritis
Background
Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in spondyloarthritis, remains unknown. We considered the role of neutrophils in the experimental SKG mouse model of SpA and in human axial entheses.
Methods
Early inflammatory infiltrates in the axial and peripheral entheseal sites in SKG mice were evaluated using immunohistochemistry and laser capture microdissection of entheseal tissue. Whole transcriptome analysis was carried out using Affymetrix gene array MTA 1.0, and data was analyzed via IPA. We further isolated neutrophils from human peri-entheseal bone and fibroblasts from entheseal soft tissue obtained from the axial skeleton of healthy patients and determined the response of these cells to fungal adjuvant.
Results
Following fungal adjuvant administration, early axial and peripheral inflammation in SKG mice was characterized by prominent neutrophilic entheseal inflammation. Expression of transcripts arising from neutrophils include abundant mRNA for the alarmins S100A8 and S100A9. In normal human axial entheses, neutrophils were present in the peri-entheseal bone. Upon fungal stimulation in vitro, human neutrophils produced IL-23 protein, while isolated human entheseal fibroblasts produced chemokines, including IL-8, important in the recruitment of neutrophils.
Conclusion
Neutrophils with inducible IL-23 production are present in uninflamed human entheseal sites, and neutrophils are prominent in early murine spondyloarthritis-related enthesitis. We propose a role for neutrophils in the early development of enthesitis.
Journal Article
Ultrasonic-Assisted Extraction, Structural Characterization, Chain Conformation, and Biological Activities of a Pectic-Polysaccharide from Okra (Abelmoschus esculentus)
The purpose of this study was to better understand the chemical characteristics and chain conformation of okra polysaccharides extracted by ultrasonic-assisted extraction. A pectic-polysaccharide, named OPP-D, was obtained, which was mainly composed of rhamnose, galacturonic acid, and galactose with a molar ratio of 1.01:1.00:2.31. Combined with NMR analysis, -4)-α-d-GalAp-(1,2,4)-α-l-Rhap-(1- were identified as the backbone with galactan side chains substituted partly at O-4 of Rhap. Molecular weight and radius of gyration of OPP-D were determined as 2.19 × 105 Da and 27.0 nm, respectively. OPP-D was determined as an air-core sphere with branching chains in 0.9% NaCl solution by high-performance size-exclusion chromatography coupled with multi-angle laser light scattering and dynamic light scattering for the first time. Moreover, OPP-D exhibited typical shear-thinning behavior. In addition, OPP-D exhibited remarkable in vitro antioxidant activities and prebiotic activities, while the relatively high molecular weight, high degree of esterification, high content of uronic acids, and highly branched globular conformation of OPP-D might contribute to its in vitro anti-diabetic activities and binding capacities. Results can contribute to a better understanding of the structure–bioactivity relationship of OPPs, and OPP-D has great potential applications in the functional food and pharmaceutical industries.
Journal Article
The role of survival motor neuron protein (SMN) in protein homeostasis
Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant efforts have been made to reveal the molecular functions of this ubiquitously expressed protein. Resulting research demonstrated that SMN plays important roles in multiple fundamental cellular homeostatic pathways, including a well-characterised role in the assembly of the spliceosome and biogenesis of ribonucleoproteins. More recent studies have shown that SMN is also involved in other housekeeping processes, including mRNA trafficking and local translation, cytoskeletal dynamics, endocytosis and autophagy. Moreover, SMN has been shown to influence mitochondria and bioenergetic pathways as well as regulate function of the ubiquitin–proteasome system. In this review, we summarise these diverse functions of SMN, confirming its key role in maintenance of the homeostatic environment of the cell.
Journal Article
Kinetically stabilized ferroelectricity in bulk single-crystalline HfO2:Y
HfO
2
, a simple binary oxide, exhibits ultra-scalable ferroelectricity integrable into silicon technology. This material has a polymorphic nature, with the polar orthorhombic (
Pbc
2
1
) form in ultrathin films regarded as the plausible cause of ferroelectricity but thought not to be attainable in bulk crystals. Here, using a state-of-the-art laser-diode-heated floating zone technique, we report the
Pbc
2
1
phase and ferroelectricity in bulk single-crystalline HfO
2
:Y as well as the presence of the antipolar
Pbca
phase at different Y concentrations. Neutron diffraction and atomic imaging demonstrate (anti)polar crystallographic signatures and abundant 90°/180° ferroelectric domains in addition to switchable polarization with negligible wake-up effects. Density-functional-theory calculations indicate that the yttrium doping and rapid cooling are the key factors for stabilization of the desired phase in bulk. Our observations provide insights into the polymorphic nature and phase control of HfO
2
, remove the upper size limit for ferroelectricity and suggest directions towards next-generation ferroelectric devices.
Hafnia ferroelectrics are of industrial interest owing to their compatibility with silicon-based electronics, but the ferroelectricity only exists in nanoscale films. Here, using a floating zone growth approach, ferroelectricity in bulk Y-doped hafnia is demonstrated.
Journal Article
Altermagnetism with non-collinear spins
Altermagnetism is introduced as a category of magnetic states with ‘collinear’ antiferromagnetic spins and alternating variations of local structures around spins in such a way that the symmetry allows typical ferromagnetic behaviors. Altermagnets exhibiting ferromagnetic behaviors without any external perturbations (type-I) turn out to belong to the ferromagnetic point group. Other altermagnets (type-II and type-III) can have ferromagnetic behaviors only with external perturbations such as electric current or stress, which conserve parity-time-reversal (PT) symmetry. All types of altermagnets themselves have broken PT symmetry. The concept of altermagnetism can be extended to accommodate non-collinear spins and multiple local-structure variations.
Journal Article
A method of linking functional and structural connectivity analysis in urban green infrastructure network construction
Accelerated urbanization and population growth lead to the fragmentation of urban green space and loss of biodiversity. There are few studies on the integration of structural and functional connectivity to solve this problem. Our study aims to draw up a methodology to synthesize two methods of connectivity evaluation, accordingly, to construct an urban green infrastructure (UGI) network which is of great significance to maintain the stability of the urban ecosystem. Taking Beijing as a study area, we first used Morphological Spatial Pattern Analysis (MSPA) to identify the source patches, then combined with the graph theory-based landscape metrics to discuss the effect of different diffusion distances on the regional landscape connectivity and classify the importance level of the source patches. Finally, we used both least-cost path (LCP) and circuit theory to construct network and identify pinch areas in corridors for network optimization. The results show that (1) the landscape connectivity of the study area is obviously polarized. Source patches in mountain and hilly areas have good ecological bases and large areas, and the density of corridors is relatively high, which makes a large contribution to the overall landscape connectivity; Source patches in plain areas are severely fragmented, and there are only a small number of potential corridors connecting urban areas and suburban areas. (2) The UGI network is composed of 70 source patches and 148 potential corridors. The diffusion distance that is most beneficial to improve landscape connectivity is 20–25 km. (3) 6 pinch areas that are of great significance for improving the connectivity of the landscape present the coexistence of high migration resistance and large optimization potential, and urgently need to be restored first. This study provides a method to combine the structural and the functional analysis to construct a UGI network and formulate more scientifical protection strategies for planning departments.
Journal Article