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Background Colorectal cancer (CRC) poses a significant clinical challenge because of drug resistance, which can adversely impact patient outcomes. Recent research has shown that abnormalities within the tumor microenvironment, especially hyperglycemia, play a crucial role in promoting metastasis and chemoresistance, and thereby determine the overall prognosis of patients with advanced CRC. Methods This study employs data mining and consensus molecular subtype (CMS) techniques to identify pitavastatin and atorvastatin as potential agents for targeting high glucose-induced drug resistance in advanced CRC cells. CRC cells maintained under either low or high glucose conditions were established and utilized to assess the cytotoxic effects of pitavastatin and atorvastatin, both with and without 5-fluorouracil (5-FU). CRC 3D spheroids cultured were also included to demonstrate the anti-drug resistance of pitavastatin and atorvastatin. Results A bioinformatics analysis identified pitavastatin and atorvastatin as promising drug candidates. The CMS4 CRC cell line SW480 (SW480-HG) was established and cultured under high glucose conditions to simulate hyperglycemia-induced drug resistance and metastasis in CRC patients. Pitavastatin and atorvastatin could inhibit cell proliferation and 3D spheroid formation of CMS4 CRC cells under high glucose conditions. In addition, both pitavastatin and atorvastatin can synergistically promote the 5-FU-mediated cytotoxic effect and inhibit the growth of 5-FU-resistant CRC cells. Mechanistically, pitavastatin and atorvastatin can induce apoptosis and synergistically promote the 5-FU-mediated cytotoxic effect by activating autophagy, as well as the PERK/ATF4/CHOP signaling pathway while decreasing YAP expression. Conclusion This study highlights the biomarker-guided precision medicine strategy for drug repurposing. Pitavastatin and atorvastatin could be used to assist in the treatment of advanced CRC, particularly with CMS4 subtype CRC patients who also suffer from hyperglycemia. Pitavastatin, with an achievable dosage used for clinical interventions, is highly recommended for a novel CRC therapeutic strategy.

Previous researchers of impression management have focused on the tactics of supervisor-targeted ingratiation, self-promotion, and exemplification, and neglected those targeting coworkers. Thus, we focused on the supplication tactics that employees use toward coworkers. Data were collected from 238 supervisor-subordinate dyads working at technology companies in Taiwan. Results showed that the higher the self-efficacy, the less likely employees were to use supplication tactics. This negative relationship was also stronger when leader-member exchange (LMX) quality was high. However, when employees used supplication tactics, high LMX did not buffer supervisors' negative assessment of their organizational citizenship behavior (OCB). Thus, employees' supplication tactics damaged supervisors' evaluation of their OCB. Theoretical and practical implications are discussed.

Previous researchers of impression management have focused on the tactics of supervisor-targeted ingratiation, self-promotion, and exemplification, and neglected those targeting coworkers. Thus, we focused on the supplication tactics that employees use toward coworkers. Data were collected from 238 supervisor--subordinate dyads working at technology companies in Taiwan. Results showed that the higher the self-efficacy, the less likely employees were to use supplication tactics. This negative relationship was also stronger when leader--member exchange (LMX) quality was high. However, when employees used supplication tactics, high LMX did not buffer supervisors' negative assessment of their organizational citizenship behavior (OCB). Thus, employees' supplication tactics damaged supervisors' evaluation of their OCB. Theoretical and practical implications are discussed.

Previous researchers of impression management have focused on the tactics of supervisor-targeted ingratiation, self-promotion, and exemplification, and neglected those targeting coworkers. Thus, we focused on the supplication tactics that employees use toward coworkers. Data were collected from 238 supervisor--subordinate dyads working at technology companies in Taiwan. Results showed that the higher the self-efficacy, the less likely employees were to use supplication tactics. This negative relationship was also stronger when leader--member exchange (LMX) quality was high. However, when employees used supplication tactics, high LMX did not buffer supervisors' negative assessment of their organizational citizenship behavior (OCB). Thus, employees' supplication tactics damaged supervisors' evaluation of their OCB. Theoretical and practical implications are discussed.

This article focuses on educational mobility as a source of heterogeneity in the socialization experience and its association with cultural capital. This study utilizes data collected from the 2007 Taiwan Social Change Survey. The main research findings are as follows: (1) Five clusters were identified in Taiwanese society in terms of musical and cultural capital; (2) Although the demarcation of cultural capital is apparent between univorous and omnivorous groups, there is also heterogeneity within omnivorous and univorous groups; (3) Family background is the most important social context that shapes musical and cultural capital, but is not the only one to do so. The musical and cultural capital added during social mobility has become critical to the distinction, providing weak support for a cultural reproduction model. (4) The omnivorous traits of persons who experienced upward mobility resulted from the two major social practices of \"rejection\" and \"imitation,\" which transformed the cross-boundary mobility

本研究聚焦在作為一種異質性社會化經驗來源的教育流動及其與文化資本的關聯性探討。本研究使用2007年施測的「臺灣地區社會變遷基本調查」資料做分析。研究的主要發現：一、臺灣社會透過音樂文化資本區辨出幾乎不消費、純食流行音樂、純食高雅音樂、雜食且偏好在地音樂、不一致的雜食等五種集群。二、音樂文化資本的劃界不僅出現在純食與雜食群體之間，雜食和純食群體內部還有各自的異質性。三、家庭背景是形塑音樂文化資本的最主要社會化脈絡，但並非唯一，社會流動過程所添加的音樂文化資本成了秀異的關鍵，故文化再製模型弱假設獲得支持。四、向上流動者的雜食特質是來自跨界流動經驗轉化為「排拒」和「仿效」兩種主要的社會實踐行動，上層低度流動者的雜食則是「區辨仿效者」和「文化善意」的結果。 This article focuses on educational mobility as a source of heterogeneity in the socialization experience and its association with cultural capital. This study utilizes data collected from the 2007 Taiwan Social Change Survey. The main research findings are as follows: (1) Five clusters were identified in Taiwanese society in terms of musical and cultural capital; (2) Although the demarcation of cultural capital is apparent between univorous and omnivorous groups, there is also heterogeneity within omnivorous and univorous groups; (3) Family background is the most important social context that shapes musical and cultural capital, but is not the only one to do so. The musical and cultural capital added during social mobility has become critical to the distinction, providing weak support for a cultural reproduction model. (4) The omnivorous traits of persons who experienced upward mobility resulted from the two major social practices of “rejection” and “imitation,” which transformed the cross-boundary mobility experience, whereas the low mobility experienced by individuals with omnivorous traits in high social classes resulted from “distinction imitators” and “cultural goodwill.”

This article focuses on educational mobility as a source of heterogeneity in the socialization experience and its association with cultural capital. This study utilizes data collected from the 2007 Taiwan Social Change Survey. The main research findings are as follows: (1) Five clusters were identified in Taiwanese society in terms of musical and cultural capital; (2) Although the demarcation of cultural capital is apparent between univorous and omnivorous groups, there is also heterogeneity within omnivorous and univorous groups; (3) Family background is the most important social context that shapes musical and cultural capital, but is not the only one to do so. The musical and cultural capital added during social mobility has become critical to the distinction, providing weak support for a cultural reproduction model. (4) The omnivorous traits of persons who experienced upward mobility resulted from the two major social practices of “rejection” and “imitation,” which transformed the cross-boundary mobility

Since the publication of Distinction by Pierre Bourdieu in 1984, the idea of using cultural tastes as the standard for differentiating social groups has drawn much attention. This study utilizes data collected from the Taiwan Social Change Survey conducted in 1997 and 2007, in order to explore the validity of the views proposed by Bourdieu in Distinction. The study found that the phenomenon of cultural omnivorousness was the main characteristic of cultural consumption behavior in both 1997 and 2007. Not only did cultural omnivores display broadness of tastes, their tastes also exhibited differentiating effects across different social classes. The study also found that there is a trend among omnivores toward a more individualized consumption pattern. In addition, cultural activities are multi-faceted, and will undergo historical changes over time. The major factor that affects cultural tastes is an individual's education level, with the secondary factor being their objective class.

自Bourdieu的《秀異》一書問世，文化品味作為區辨社會群體的指標格外受到關注，但Bourdieu強調社會群體的階級與文化品味之間具有單一對應的觀點並不符合西方社會的文化消費模式。本研究使用1997年和2007年施測的「臺灣地區社會變遷基本調查」，探討Bourdieu的秀異觀點在臺灣的有效性。研究發現文化雜食是1997年和2007年主要的文化消費行為特質，高階層者屬於多元文化品味的雜食類型，低階層者的文化偏好則是較為單一性的純食型態，同時也發現文化品味從雜食性轉向個人化消費型態的變遷。此外，文化活動具有多面向的特質，也會隨著時間而有時代意義的變遷；影響文化品味最主要的因素是個人的教育，客觀階級位置的重要性次之

自Bourdieu的《秀異》一書問世，文化品味作為區辨社會群體的指標格外受到關注，但Bourdieu強調社會群體的階級與文化品味之間具有單一對應的觀點並不符合西方社會的文化消費模式。本研究使用1997年和2007年施測的「臺灣地區社會變遷基本調查」，探討Bourdieu的秀異觀點在臺灣的有效性。研究發現文化雜食是1997年和2007年主要的文化消費行為特質，高階層者屬於多元文化品味的雜食類型，低階層者的文化偏好則是較為單一性的純食型態，同時也發現文化品味從雜食性轉向個人化消費型態的變遷。此外，文化活動具有多面向的特質，也會隨著時間而有時代意義的變遷；影響文化品味最主要的因素是個人的教育，客觀階級位置的重要性次之。 Since the publication of Distinction by Pierre Bourdieu in 1984, the idea of using cultural tastes as the standard for differentiating social groups has drawn much attention. This study utilizes data collected from the Taiwan Social Change Survey conducted in 1997 and 2007, in order to explore the validity of the views proposed by Bourdieu in Distinction. The study found that the phenomenon of cultural omnivorousness was the main characteristic of cultural consumption behavior in both 1997 and 2007. Not only did cultural omnivores display broadness of tastes, their tastes also exhibited differentiating effects across different social classes. The study also found that there is a trend among omnivores toward a more individualized consumption pattern. In addition, cultural activities are multi-faceted, and will undergo historical changes over time. The major factor that affects cultural tastes is an individual’s education level, with the secondary factor being their objective class.