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"Roman, Dave"
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Astronaut Academy. Re-entry
Hakata Soy, having recently fallen in love, discovers that a sinister culprit is stalking the halls of Astronaut Academy, impersonating the crush-objects of students and making off with their extra hearts.
Book
Saturday Talk
Let's see if we can discern a pattern here. A Democratic president appeases China; Bob Barr calls for an investigation. A Republican president appeases China; Barr is silent. Democratic presidential staffers allegedly steal the \"W\" keys off computers; Barr calls for an investigation. Republican congressional staffers disrupt the electoral process in Florida; Barr is silent. Republican congressmen admit to adulterous affairs; Barr is silent. Democratic congressman admits to affair; Barr calls for his resignation. Regarding Public Editor Mike King's column on newspaper bias (\"Explanations don't ease readers' views of bias,\" July 14): As a regular reader of The Atlanta Journal and many other periodicals and online daily newspapers as well, I am absolutely floored by the oft- heard, but never proven, stereotype of liberal bias. Maybe, just maybe, the AJC readers are right. What does it matter that the editorial staff doesn't talk to the newsroom people if the corporate culture determines attitudes and behavior? Frankly, I think your liberal, feminist, black/ lesbian rights activist Cynthia Tucker is mostly indistinguishable from the Journal-Constitution news writers with their obvious liberal, feminist, black rights and lesbian rights activism and politically correct polemics, whether they exchange daily notes or not.
Newspaper Article
Zero gravity
Hakata Soy looks to make a new start at Astronaut Academy, but his past as the leader of a futuristic superhero team catches up to him when a robot doppelganger is sent to kill him.
BOOK
Glucose metabolism links astroglial mitochondria to cannabinoid effects
Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses
1
–
5
. By contrast, astrocytes are under neuronal control through specific neurotransmitter receptors
5
–
7
. However, whether the activation of astroglial receptors can directly regulate cellular glucose metabolism to eventually modulate behavioural responses is unclear. Here we show that activation of mouse astroglial type-1 cannabinoid receptors associated with mitochondrial membranes (mtCB
1
) hampers the metabolism of glucose and the production of lactate in the brain, resulting in altered neuronal functions and, in turn, impaired behavioural responses in social interaction assays. Specifically, activation of astroglial mtCB
1
receptors reduces the phosphorylation of the mitochondrial complex I subunit NDUFS4, which decreases the stability and activity of complex I. This leads to a reduction in the generation of reactive oxygen species by astrocytes and affects the glycolytic production of lactate through the hypoxia-inducible factor 1 pathway, eventually resulting in neuronal redox stress and impairment of behavioural responses in social interaction assays. Genetic and pharmacological correction of each of these effects abolishes the effect of cannabinoid treatment on the observed behaviour. These findings suggest that mtCB
1
receptor signalling can directly regulate astroglial glucose metabolism to fine-tune neuronal activity and behaviour in mice.
In mice, persistent activation of mitochondrial cannabinoid receptors in astroglia impairs cellular glucose metabolism and lactate production, leading to an increase in redox stress in neurons and altered behavioural responses.
Journal Article
Charities got early warning
[Bernard Cave-Browne-Cave] hired [John Craig Cooper]'s fledgling firm to run fund- raising campaigns both for Big Brothers and for KIDS, which he began running full-time this spring after leaving Big Brothers. Charitable Fund Raisers has since had its licence suspended by the City of Calgary's charity campaign approving authority, amid allegations as much as $493,000 in public solicitations have not been accounted for by Cooper. [Robert Bakker] said he found it ironic that in the wake of Charitable Fund Raisers' licence suspension, his firm has since been approached by Cave-Browne-Cave to do fund-raising for KIDS - which wants to open a children's services administrative centre and a youth centre in a converted downtown block.
Newspaper Article
Slappy's tales of horror
A collection of short graphic novels featuring characters from famous \"Goosebumps\" stories includes \"Ghost Beach,\" in which two siblings investigate a local legend and discover a terrible secret about their family.
BOOK
Evaluating the Differenced Normalized Burn Ratio for Assessing Fire Severity Using Sentinel-2 Imagery in Northeast Siberian Larch Forests
Fire severity is a key fire regime characteristic with high ecological and carbon cycle relevance. Prior studies on boreal forest fires primarily focused on mapping severity in North American boreal forests. However, the dominant tree species and their impacts on fire regimes are different between North American and Siberian boreal forests. Here, we used Sentinel-2 satellite imagery to test the potential for using the most common spectral index for assessing fire severity, the differenced Normalized Burn Ratio (dNBR), over two fire scars and 37 field plots in Northeast Siberian larch-dominated (Larix cajanderi) forests. These field plots were sampled into two different forest types: (1) dense young stands and (2) open mature stands. For this evaluation, the dNBR was compared to field measurements of the Geometrically structured Composite Burn Index (GeoCBI) and burn depth. We found a linear relationship between dNBR and GeoCBI using data from all forest types (R2 = 0.42, p < 0.001). The dNBR performed better to predict GeoCBI in open mature larch plots (R2 = 0.56, p < 0.001). The GeoCBI provides a holistic field assessment of fire severity yet is dominated by the effect of fire on vegetation. No significant relationships were found between GeoCBI components (overall and substrate stratum) and burn depth within our fires (p > 0.05 in all cases). However, the dNBR showed some potential as a predictor for burn depth, especially in the dense larch forests (R2 = 0.63, p < 0.001). In line with previous studies in boreal North America, the dNBR correlated reasonably well with field data of aboveground fire severity and showed some skills as a predictor of burn depth. More research is needed to refine spaceborne fire severity assessments in the larch forests of Northeast Siberia, including assessments of additional fire scars and integration of dNBR with other geospatial proxies of fire severity.
Journal Article
A Case–Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations
Polybrominated diphenyl ethers (PBDEs) are flame retardants found in North American household products during the past four decades. These chemicals leach out in dust as products age, exposing individuals daily through inhalation and ingestion. Animal studies suggest that PBDEs disrupt sex hormones and adversely affect development of the reproductive system.
In the present study, we examined whether there is a link between maternal hair PBDE concentrations and the risk of cryptorchidism (undescended testes) in male infants; testis descent is known to be dependent on androgens.
Full-term male infants were recruited through clinics in Montreal, Toronto, and London, Canada. Boys with cryptorchidism at 3-18 months of age (
=137) were identified by pediatric urologists and surgeons; similar-aged controls (
=158) had no genitourinary abnormalities as assessed by pediatricians. Eight BDE congeners (BDE-28, -47, -99, -100, -153, -154, -183, -209) were measured by GC-MS (gas chromatography-mass spectrometry) in maternal hair samples collected at the time of recruitment.
The ∑PBDE geometric mean for maternal hair was 45.35 pg/mg for controls and 50.27 pg/mg for cases; the concentrations of three BDEs (BDE-99, -100, and -154) were significantly higher in cases than controls in unadjusted models. In adjusted models, every 10-fold increase in the concentration of maternal hair BDE-99 [OR=2.53 (95% CI: 1.29, 4.95) or BDE-100 [OR=2.45 (95% CI: 1.31, 4.56)] was associated with more than a doubling in the risk of cryptorchidism. BDE-154 [OR=1.88 (95% CI: 1.08, 3.28) was also significant.
Our results suggest that maternal exposure to BDE-99, -100, and -154 may be associated with abnormal migration of testes in the male fetus. This may be due to the anti-androgenic properties of the PBDEs. https://doi.org/10.1289/EHP522.
Journal Article
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Dysfunctional endothelium contributes to more diseases than any other tissue in the body. Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells
in vivo
by durably silencing multiple genes simultaneously, but efficient siRNA delivery has so far remained challenging. Here, we show that polymeric nanoparticles made of low-molecular-weight polyamines and lipids can deliver siRNA to endothelial cells with high efficiency, thereby facilitating the simultaneous silencing of multiple endothelial genes
in vivo
. Unlike lipid or lipid-like nanoparticles, this formulation does not significantly reduce gene expression in hepatocytes or immune cells even at the dosage necessary for endothelial gene silencing. These nanoparticles mediate the most durable non-liver silencing reported so far and facilitate the delivery of siRNAs that modify endothelial function in mouse models of vascular permeability, emphysema, primary tumour growth and metastasis.
Polymeric nanoparticles can efficiently deliver siRNAs to endothelial cells
in vivo
and silence multiple genes for weeks.
Journal Article