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The current study sought to determine whether Tribulus terrestris fruit extracts could protect rats from hepato-renal damage brought on by ivermectin. To assess the effectiveness of Tribulus terrestris extracts against liver and renal toxicity as well as related histopathological alterations, vitamin \"C\" was employed as a comparison standard medication. Thirty rats were divided into two main groups; the first main group (6 rats) received a basal diet and used as the negative group. The second main group of 24 rats received ivermectin (IVM) (200 mg / kg of body weight) for 30 days in order to develop hepatic renal toxicity. Four separate groups were created from the second main group: Group 2 received a basal diet and used as the positive control group. Groups 3 and 4 consumed a basal diet in addition to oral Tribulus terrestris (TT) ethanolic and aqueous extracts (200 mg per kg of body weight), respectively. Group (5) consumed a basal diet along with oral vitamin \"C\" (200 mg per kilogram of body weight) for 28 days. Phenolic compounds in TT extract were identified using a high-performance gas chromatograph. The outcomes proved that groups of rats administered for 28 days with Tribulus terrestris extracts as well as vitamin \"C\" at a dose of 200 mg/Kg body weight have shown improvement in feed efficiency ratio body weight gain, feed intake, function of the kidneys and liver variables serum and urinary electrolytes (sodium and potassium), some immunological profiles (interleukin 6 and interleukin 10) and antioxidant enzymes activity. The group given Tribulus terrestris ethanolic extract (200mg/Kg body weight) had the best outcomes. The biochemical evaluation was corroborated by a histopathological investigation. According to the results of this investigation, Tribulus terrestris extracts could be utilized as a successful treatment to lessen the ivermectin induced liver and kidney damage in rats because they contain many phenolic antioxidant compounds.

Indole-3-carbinol was found to have possible anticarcinogenic, antioxidant and antiatherogenic effects on the organism. The aim of the present study investigation is to evaluate the protective effect of indole-3-carbinol (I3C) against aspirin (ASA) induced effects on rat liver. Male albino rats were randomly divided into four groups of 6 animals in each. The control rats (group 1) were orally administration of distilled water for seven days and the experimental rats (groups 2-4) were treated with ASA at a dose of 500 mg/kg/body weight and I3C at a dose of 20 mg/kg/body weight either alone or in combination with each other orally, once daily for seven consecutive days. Results of the present study showed that groups treated with indole-3-carbinol possessed protective activity possibly as evidenced by the reduction of histopathological alteration and showed normal histological structure of liver. This work suggest that I3C possesses significant hepatoprotective and antioxidant properties on hepatotoxicity induction by ASA in male albino rats.

the present study investigated chemical composition of pumpkin seeds, oil and the protective effect of zinc, pumpkin seeds and pumpkin seeds oil against food coloring induced oxidative stress and hepatotoxicity in rats for three months. Thirty six male albino rats (Sprague Dawley strain) weight 140± 10g gm were investigated. Rats were divided into six groups (six rats of each). The first group (6 rats) was considerable as negative control and it was fed on basal diet .The second group fed on basal diet supplemented with (75 mg/kg diet from tartrazine& 0.4 g/ kg diet from brilliant blue (as a positive control group).The third group fed on basal diet supplemented with food colors + pumpkin seeds (25g/ kg diet). The fourth group fed on basal diet basal diet supplemented with food colors + pumpkin seeds oil (8mg/ kg diet). The fifth group fed on basal diet supplemented with food colors + pumpkin seeds (25g/ kg diet) + (25 mg Zn/g diet).The sixth group fed on basal diet supplemented with food colors + pumpkin seeds oil (8mg/kg diet) + (25 mg Zn/g diet). At the end of the experiment biological data were calculated, blood samples were taken. Serum was separated to biochemical analysis. The results revealed that the chemical composition of pumpkin seeds indicates the presence of high amounts of lipids, protein, crude fiber, total carbohydrates, ash, zinc and also low moisture content, respectively. The control (+ve) group showed a significant decrease in weight gain; liver function, kidney function, liver GPX & SOD and catalase, but a significant increase in liver LPX compared with control (- ve) group. Serum total cholesterol and LDL-C showed significant increase of C+ve group, but all treated groups with PS, PSO, PS+Z and PSO+Z showed improvement in liver function , kidney function ,lipid profile, liver GPX& SOD and catalase compared with C+ve group. In conclusion, the administration of pumpkin seeds, pumpkin seeds oil and zinc can lower the side effects of food colors toxicant, have antioxidant and hepatoprotective potential.

Forty-two adult male of Sprague Dawley strain rats classified into control (-ve) group and five rat groups which administered 2 g/kg paracetamol by stomach tube to induced liver necrosis. One of them served as control (+ve) rat group while the others were physalis powder, physalis juice, aqua physalis extract and methanol physalis extract treated rat groups. The study assigned for eight weeks. The results showed that control (+ve) rat group showed a significant decrease in final weight, weight gain , food efficiency ratio(FER) , food intake , serum high denisity lipoprotein cholesterol (HDLc) ,Iiver glutathione peroxidase (GPX), superoxide dismutase (SOD) , catalase, triglyceride and glycogen. On the hand, it showed a significant increase in serum cholesterol, triglyceride, low denisity lipoprotein cholesterol (LDLc), very low denisity lipoprotein cholesterol (VLDLc), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and cholesterol/HDLc ratio. These changes were accompanied by an increase in liver malondialdehyde (MDA), cholesterol and total lipids compared to control (-ve) group. Both physalis powder and physalis juice treated groups showed a significant decrease in final weight, weight gain, FER, liver catalase and glycogen but showed a significant increase in liver MDA and total lipids compared to control (- ve) group. Physalis powder, physalis juice, aqua physalis extract and methanol physalis extract treated groups showed a significant increase in cholesterol/HDLc ratio, serum LDLc, ALT, AST , ALP ,LDH and liver MDA and a significant decrease in liver GPX and SOD compared to control (-ve) group. It is concluded that consumption of physalis can reduce liver damage in the experimental rats.