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The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by cndosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.

The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the forma- tion of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the forma- tion of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting.

Although Beijing has carried out municipal solid waste （MSW） source separation since 1996, it has largely been ineffective. In 2012, a ＂Green House＂ program was established as a new attempt for central sorting. In this study, the authors used material flow analysis （MFA） and cost benefit analysis （CBA） methods to investigate Green House＇s environment and economic feasibility. Results showed that the program did have significant environmental benefits on waste reduction, which reduced the amount of waste by 34%. If the Green House program is implemented in a residential community with wet waste ratio of 66%, the proportion of waste reduction can reach 37%. However, the Green House is now running with a monthly loss of 1982 CNY. This is mainly because most of its benefits come from waste reduction （i.e., 5878 CNY per month）, which does not turn a monetary benefit, but is instead distributed to the whole of society as positive environmental externalities. Lack of government involvement, small program scale, and technical/managerial deficiency are three main barriers of the Green House. We, thus, make three recommendations： involve government authority and financial support, expand the program scale to separate 91.4 tons of waste every month, and use more professional equipment/technologies. If the Green House program can successfully adopt these suggestions, 33.8 tons of waste can be reduced monthly, and it would be able to flip the loss into a profit worth 35034 CNY.

The design and operation of high volume conveyor systems in distribution centers are important due to its high cost, large footprint and critical role in the system. However, there is no analytical model available. In this paper, we study the characteristics of the conveyor sortation system, develop a generic model of a complex conveyor network. We then use the Delay and Stock abstraction to develop an approximate analytical method using sample path analysis and dynamic network flow model. The decision variables include length of accumulation segments and the speeds of conveyor components aforementioned decision variables. This analytical solution provides faster analysis, insights and useful subgradient with respect to the decision variables.