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America Unbound: The Bush Revolution in Foreign Policy
George W. Bush has launched a revolution in American foreign policy. He has redefined how America engages the world, shedding the constraints that friends, allies, and international institutions impose on its freedom of action. He has insisted that an America unbound is a more secure America. How did a man once mocked for knowing little about the world come to be a foreign policy revolutionary? In America Unbound, Ivo H. Daalder and James M. Lindsay dismiss claims that neoconservatives have captured the heart and mind of the president. They show that George W. Bush has been no one's puppet. He has been a strong and decisive leader with a coherent worldview that was evident even during the 2000 presidential campaign. Daalder and Lindsay caution that the Bush revolution comes with significant risks. Raw power alone is not enough to preserve and extend America's security and prosperity in the modern world. The United States often needs the help of others to meet the challenges it faces overseas. But Bush's revolutionary impulse has stirred great resentment abroad. At some point, Daalder and Lindsay warn, Bush could find that America's friends and allies refuse to follow his lead. America will then stand alone-a great power unable to achieve its most important goals.
eBook
Networked David Lynch : critical perspectives on cinematic transmediality
The first multi-disciplinary reconsideration of Lynch's œuvreOffers multi-disciplinary approaches to transmedialityProvides new readings of David Lynch's open œuvreExplores new methods and approaches in film studies, e.g. videographic criticismNetworked David Lynch is a multi-disciplinary reconsideration of Lynch's œuvre in the context of the challenges and opportunities offered by transmedia environments and networks of the 21st century. This collection builds on state-of-the-art-research concepts like video-graphic criticism and video essays to provide a fresh and important approach to any study of David Lynch's œuvre. As such, Networked David Lynch is an attractive entry point to current media theory and recent film history, appealing to cinephiles, academics, researchers, and students.This multi-disciplinary reader provides immediate relevance to university courses focusing on modern film history and on current theory in film, television, and media studies. The scope of approaches featured in the book provides an informative basis for courses on transmedia and media convergence, sound studies, musicology, cultural studies, and American studies.
Book
The film paintings of David Lynch : challenging film theory
One of the most distinguished filmmakers working today, David Lynch is a director whose vision of cinema is firmly rooted in fine art. He was motivated to make his first film as a student because he wanted a painting that \"would really be able to move.\" Most existing studies of Lynch, however, fail to engage fully with the complexities of his films' relationship to other art forms. The Film Paintings of David Lynch fills this void, arguing that Lynch's cinematic output needs to be considered within a broad range of cultural references.
Aiming at both Lynch fans and film studies specialists, Allister Mactaggart addresses Lynch's films from the perspective of the relationship between commercial film, avant-garde art, and cultural theory. Individual Lynch films—The Elephant Man, Blue Velvet, Twin Peaks, Lost Highway, The Straight Story, Mulholland Drive, Inland Empire—are discussed in relation to other films and directors, illustrating that the solitary, or seemingly isolated, experience of film is itself socially, culturally, and politically important. The Film Paintings of David Lynch offers a unique perspective on an influential director, weaving together a range of theoretical approaches to Lynch's films to make exciting new connections among film theory, art history, psychoanalysis, and cinema.
eBook
Stan Smith : some people think I'm a shoe!
\"The first definitive volume that celebrates the best-selling Adidas sneaker with a cultlike global following. Featuring original imagery, historical photos, an exclusive portrait series by artist Juergen Teller, and contributions from style arbiters such as Raf Simons and Pharrell, plus aninterview and anecdotes from the man behind the sneaker, Stan Smith.\" -- Amazon.com
Book
Alternative splicing as a regulator of development and tissue identity
Key Points
Alternative splicing explains how a single gene can generate more than one mRNA transcript, thus expanding the complexity of the proteome.
During normal development, a large number of alternative splicing changes occur, and it is now apparent that these transitions between alternatively spliced isoforms contribute to the acquisition of adult tissue functions and identity.
Individual splicing changes are coordinated during development, establishing splicing networks.
As a result of recent progress, we now better understand the mechanisms that coordinate alternative splicing networks and the roles of these networks in cell differentiation, organ development and tissue homeostasis.
Alternative splicing expands the complexity of the proteome by generating multiple transcript isoforms from a single gene. Numerous alternative splicing events occur during cell differentiation and tissue maturation, suggesting that alternative splicing supports proper development. Recent studies shed light on how alternative splicing and its coordination contribute to organ development and tissue homeostasis.
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.
Journal Article
The biogenesis and emerging roles of circular RNAs
Circular RNAs (circRNAs) are produced from precursor RNA back-splicing. Recent findings reveal the complexity of the biogenesis of circRNAs and their cell type-specific expression. They also show that circRNAs can shape eukaryotic transcriptomes by sequestering microRNAs and by regulating transcription and interfering with splicing.
Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels, recent findings have shed new light on their cell type-specific and tissue-specific expression and on the regulation of their biogenesis. Furthermore, the data indicate that circRNAs shape gene expression by titrating microRNAs, regulating transcription and interfering with splicing, thus effectively expanding the diversity and complexity of eukaryotic transcriptomes.
Journal Article
The biogenesis, biology and characterization of circular RNAs
Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by specific cis-acting elements and trans-acting factors. Some circRNAs are abundant and evolutionarily conserved, and many circRNAs exert important biological functions by acting as microRNA or protein inhibitors (‘sponges’), by regulating protein function or by being translated themselves. Furthermore, circRNAs have been implicated in diseases such as diabetes mellitus, neurological disorders, cardiovascular diseases and cancer. Although the circular nature of these transcripts makes their detection, quantification and functional characterization challenging, recent advances in high-throughput RNA sequencing and circRNA-specific computational tools have driven the development of state-of-the-art approaches for their identification, and novel approaches to functional characterization are emerging.
Journal Article