Asset Details
Do you wish to reserve the book?
Candida auris persists in the vaginal microaerobic niche in the absence of interleukin-17A
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Candida auris persists in the vaginal microaerobic niche in the absence of interleukin-17A
Do you wish to request the book?
Candida auris persists in the vaginal microaerobic niche in the absence of interleukin-17A
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Candida auris persists in the vaginal microaerobic niche in the absence of interleukin-17A
2025
Overview
Candida auris is an emerging fungal species, and several reports have recently identified C. auris in patients with vulvovaginal candidiasis (VVC), although few studies have investigated the relationship between C. auris and VVC or the associated host factors. Our study, using the VVC mouse model, confirmed persistent vaginal colonization by C. auris , especially clades I, III, and IV, along with reduced neutrophil infiltration and lower S100A8 secretion under interleukin-17A-deficient conditions. In addition, in vitro assays demonstrated enhanced C. auris adhesion to vaginal epithelial cells, especially microaerobic conditions imitating human vaginal microenvironments. Our findings suggest that C. auris exhibits strong vaginal tropism, and IL-17A plays a critical role in controlling C. auris -associated VVC.
Publisher
American Society for Microbiology
Subject
/ Animals
/ Candida auris - growth & development
/ Candidiasis, Vulvovaginal - immunology
/ Candidiasis, Vulvovaginal - microbiology
/ Clinical Microbiology and Infectious Diseases
/ Epithelial Cells - microbiology
/ Female
/ Humans
/ Mice
/ Microbial Pathogenesis and Immunology
/ S100A8
/ Special Series: Candida auris
/ Urinary Tract Infections (UTIs)
